Refine by
In Vitro Culture Articles & Analysis
22 articles found
These specialized cells play a crucial role in the filtration barrier of the kidneys, and their immortality allows for extended experimentation beyond the limitations of primary cell cultures. Podocytes are unique epithelial cells located in the glomerulus, a key component of the nephron responsible for filtering blood. ...
Various protocols exist for obtaining these cells from different sources, with bone marrow and adipose tissue being the most commonly used. Once isolated, hMSCs can be cultured in vitro under specific conditions that support their proliferation while maintaining their stemness. This ability to expand in culture is critical for producing ...
Types of ADME Testing Services To ensure comprehensive evaluation, various testing methodologies are employed, including in vitro and in vivo studies, alongside computational modeling techniques. In vitro tests often involve using cell cultures or biological fluids to assess how drugs are absorbed and metabolized. ...
They exhibit high levels of keratinocyte markers, which are essential for maintaining the structural integrity and function of the corneal epithelium. These cells can be cultured in vitro, allowing researchers to study their behavior under controlled conditions. ...
The most important and critical step in cell culture is the selection of an appropriate growth medium for in vitro culture. ...
By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro cell cultures and the complexities of in vivo models. The versatility and precision of this technique have positioned PCLS as an invaluable tool in advancing our understanding of lung ...
Using 2D cell culture systems can limit the predictive power of the cellular interactions. However, the 3D in vitro cultures provide a bridge between the conventional 2D cultures and in vivo studies. It was shown that in vitro 3D cultures recapture physiological cell-cell and cell-environment ...
Furthermore, the nanoformulation platform includes in vitro and in vivo testing capabilities to evaluate the efficacy, safety, and stability of the nanoformulations. In vitro studies involve using cell cultures to test the drug release and cytotoxicity, while in vivo studies involve animal models to assess the biodistribution, pharmacokinetics, ...
These models help analyze molecular characteristics, control cell culture conditions, and facilitate functional testing. Moreover, they can further elucidate the targets and provide an effective environment for developing new drugs. The related systems of the services include but are not limited to in vitro 2D & 3D culture systems, ...
Hepatocytes are the chief functional cells of the liver, responsible for the selective uptake, metabolism and excretion of most drugs. Cells for use in plate cultures or suspension assays represent a key tool for predicting properties such as hepatotoxicity, metabolism, and potential drug-drug interactions. ...
These models include in vivo animal models, in vitro cell culture models, in silico (computer-based) models, and genetically modified organism models. ...
These models stem from animal models to in vitro and in silico models, each playing a unique role in observing the disease. ...
Studies have shown that CPP-paclitaxel compounds are more effective than paclitaxel alone in both in vitro cell cultures and animal models. The activity of the drug was also observed in paclitaxel-resistant cells. ...
These models stem from animal models to in vitro and in silico models, each playing a unique role in observing the disease. ...
In fact, it is not difficult to see that these advanced technologies are all related to cell culture. In order to maintain efficient growth, proliferation, and differentiation during in vitro cell culture, many cell cultures require the addition of various cytokines. ...
Contexte Myasthenia gravis (MG) is an autoimmune disease caused by the presence of antibodies directed against components of the muscle membrane located at the neuromuscular junction. In the majority of cases, these are autoantibodies directed against the acetylcholine receptor (AChR). The origin of the autoimmune response is not known, but thymic abnormalities and defective regulation of the ...
Studies have also shown that CPP-paclitaxel compounds are more effective than paclitaxel alone in both in vitro cell cultures and animal models. In addition, drug activity was also observed in paclitaxel-resistant cells. 3. ...
The addition of BOC amino acids to the environment leads to the synthesis of the Cas9 protein, which stimulates the activity of the gene editing system. Using in vitro cell culture models and transgenic mouse models, the researchers demonstrated that this novel CRISPR/Cas9 gene editing system exhibits gene editing activity only in the presence of BOC unnatural ...
Developing an Inflammatory RepliGut® Model There are currently no in vitro models that completely model inflammatory diseases of the intestine. ...
Altis Biosystems tackled this challenge one step at a time. The first goal was to culture bacteria tolerant to oxygen on the RepliGut® system, which comprises mammalian cells grown on a two-dimensional surface separated by two accessible compartments — commonly known as a Transwell system, here cells are cultured on a permeable membrane with a ...