In Vitro Cytotoxicity Articles & Analysis
3 articles found
At present, ADC drugs use humanized monoclonal antibodies to modify the Fc fragment to enhance its ADCC (antibody-dependent cell-mediated cytotoxicity) effects and CDC (complement-dependent cytotoxicity) effects. ...
Abstract Purpose: To develop new therapies for children with solid tumors, we tested the cytotoxicity of natural killer (NK) cells expanded by coculture with K562-mb15-41BBL cells. We sought to identify the most sensitive tumor subtypes, clarify the molecular interactions regulating cytotoxicity, and determine NK antitumor potential in vivo. Experimental ...
Based on the reports suggesting that exposures to low doses of ionising radiation may impede tumour development and/or trigger the activity of natural anti-neoplastic defence mechanisms we demonstrate in the present study that single whole-body irradiations of mice with 0.1 or 0.2 Gy X-rays significantly decreased the number of the induced tumour colonies in the lungs and that the effect was ...