In Vitro Dissolution Experiment Articles & Analysis
11 articles found
Most of the old drugs are currently limited in their effectiveness because of poor pharmacokinetics, simple clearance by the body and cytotoxicity. Nanoparticle technology in particular, Nano drug delivery system is getting a lot of attention and application in medicine in the recent years. Since it is small (1100nm), targets well, and stays in the circulation long enough, NPs are a good ...
Proteolysis Targeting Chimeras (PROTACs) are a novel approach for degrading target proteins. Recently, a new split-and-mix PROTAC (SM-PROTAC) system based on liposome self-assembly, known as LipoSM-PROTAC, was reported in the Journal of the American Chemical Society. The LipoSM-PROTAC system exhibits selective degradation of target proteins, with folate serving as a key ligand. In this study, the ...
In recent years, PROteolysis TArgeting Chimeras (PROTAC), which utilizes the cell's own degradation mechanisms to eliminate specific disease-related proteins, has emerged as one of the most promising methods. Apart from PROTAC, various targeted protein degradation (TPD) strategies are emerging, involving molecular glue, Autophagy-Targeting Chimera (AUTEC), Autophagosome Tethering Compound ...
A new structural target for drug development against COVID-19 has been unveiled today by Sibylla Biotech in collaboration with the Italian National Institute of Nuclear Physics (INFN), the University of Trento and University of Perugia.The breakthrough drug discovery strategy pioneered by Sibylla in this study would not only promise to reduce the risk of drug resistance and harmful side effects, ...
The use of Proteolysis Targeting Chimeras (PROTACs) to degrade dysfunctional proteins has shown great potential to target proteins that were previously considered “undruggable”, and several projects have entered clinical evaluation worldwide. Aberrant protein degradation, in fact, is also a pathogenic mechanism in some diseases, such as cystic fibrosis (CF) and some forms of cancer. ...
Pancreatic cancer is a highly malignant digestive system tumor, and the five-year survival rate of patients after diagnosis is only about 10%. Changes in metabolism are one of the important features of tumor cells. Tumor cells undergo metabolic reprogramming to generate the substances, energy, and redox forces required for their rapid proliferation. The proliferation of pancreatic ductal ...
Epstein-Barr Virus (EBV) is a large enveloped virus of double-stranded DNA among the eight known herpesviruses. After EBV infection of cells, it accumulates in the nucleus, and there are two life cycles, with alternating phases of latency and lysis. EBV infection is associated with a variety of human malignancies and malignant tissue proliferative diseases, including malignant lymphoma, gastric ...
Abstract Transplantation of pancreatic islets has been shown to be effective, in some patients, for the long-term treatment of type 1 diabetes. However, transplantation of islets into either the portal vein or the subcutaneous space can be limited by insufficient oxygen transfer, leading to islet loss. Furthermore, oxygen diffusion limitations can be magnified when islet numbers are increased ...
The research of atmospheric plasma’s use for medical treatments has gathered apace over recent years. Plasma comprises charged particles as well as a range of other active components that are thought to interact with the body to produce desired affects in plasma medicine such as; electric current, UV radiation and reactive gas species these components are thought to be able to act ...
Introduction In recent years, contaminated feed has been confirmed as a vehicle for transmission of porcine epidemic diarrhea virus (PEDV). It was also demonstrated that a number of additional viruses, such as Seneca Valley virus, feline calicivirus, bovine herpesvirus-1, porcine sapelovirus, and porcine reproductive and respiratory syndrome virus (PRRSV), could maintain infectivity in feed ...
In recent years, gold nanoparticles (GNP) have been proposed as sensitising agents in radiotherapy. Several studies, performed both through Monte Carlo simulation of dosimetric and microdosimetric enhancement in presence of GNPs and through in–vitro experiments, have clearly shown the powerfulness of such a technique in radiotherapy. Aim of the present work is to estimate the dose enhancement ...