In Vitro Drug Articles & Analysis
11 articles found
The services tend to accelerate the discovery and optimization of molecule drugs with a strict quality control system. Small molecule drugs are characterized by their low molecular weight and simple chemical structures. ...
The process of iPSC differentiation to neurons and neuronal cells is of special importance for neurobiology and related disorders, considering the dearth of clinically relevant in vitro models available for research, drug screening and development, as well as the lack of therapy to reverse neuronal damage. Benefits and advantages of iPSC differentiation to ...
In vitro DMPK services provide an array of tests that simulate the human body's response to a drug. ...
Since these cells mimic the properties of the liver, researchers can evaluate the metabolism, drug-drug interaction and toxicity of drug candidates in a cost-effective manner. Pooled Human Cryopreserved Hepatocytes In drug development, primary human hepatocytes are the most suitable system for uptake, metabolism, clearance, ...
Uses of Recombinant Human Collagen Due to its good biocompatibility, low immunogenicity, stabilized property, recombinant human collagen has been widely used in tissue engineering (such as vascular scaffolds engineering, cartilage, bone defect repair), skin injury treatment, drug delivery, etc. [1]. Tissue engineering The production of recombinant human collagen enables the ...
It is also increasingly applied in drug development. FC not only can detect intracellular and extracellular components, but also detect soluble analytes in serum or plasma samples, such as cytokines, drug complexes, or anti-drug antibodies (ADA). ...
In vitro DMPK services provide an array of tests that simulate the human body's response to a drug. ...
Researchers at the University of Helsinki and the University of Eastern Finland first searched for appropriate drug targets and reusable drugs and finally discovered six candidates with antiviral effects against SARS-CoV-2. ...
Developing an Inflammatory RepliGut® Model There are currently no in vitro models that completely model inflammatory diseases of the intestine. ...
The liver plays an incredibly important role in the human body by metabolizing drugs and other compounds. Developing accurate in vitro liver models to study is a critical step in better understanding the biological dynamics of our bodies and removing our dependence on animal models. ...
If tissues are available from individuals with appropriate genetic diversity, the consequences of specific mutations superimposed onto different genetic backgrounds can be observed, providing a better understanding of how drugs will perform across a population with a certain disease. Gene-Editing Opportunities for RepliGut® Models Altis Biosystems has developed ...