In Vivo Activity Articles & Analysis
8 articles found
The effector function and biological activity of the antibody are closely related to the MOA of the ADC and should be characterized. ...
Tetrahydrocurcumin (THC), as the most active and main metabolite produced in the metabolism of curcumin in vivo, can be isolated from the cytoplasm of the small intestine and liver after curcumin administration in human or mouse. ...
This study strongly confirms that EML4-ALK is the only mutation driver in NSCLC and that inhibition of EML4-ALK activity in vivo leads to a decreased lung cancer burden. FDA approved ALK inhibitors So far, 6 ALK inhibitors have been approved by FDA, including Crizotinib (first-generation ALK drug), Ceritinib, Alectinib, Brigatinib, Ensartinib (second-generation), ...
This conditioning regimen may improve the proliferation and durable viability of adoptive T cells in vivo by balancing cytokine production in vivo and removing some immunosuppressive cells (such as regulatory T cells and myeloid-derived suppressor cells) in vivo. ...
Unfortunately, the unmodified baculovirus/insect cell platform cannot be used to manufacture recombinant glycoproteins for in vivo therapeutic applications because it does not provide terminal sialylation. ...
Saccharomyces cerevisiae Grx6 and Grx7 are two monothiol glutaredoxins whose active-site sequences (CSYS and CPYS, respectively) are reminiscent of the CPYC active-site sequence of classical dithiol glutaredoxins. ...
The aim of this work was to establish a structural model for describing the organisation, at a molecular level, of nanospheres prepared by nanoprecipitation using poly(ε-caprolactone), sorbitan monostearate and polysorbate 80. Therefore, different techniques were employed to characterise the systems such as dynamic and static light scattering, small angle X-ray scattering and release profile ...
When it is gliding, the unicellular euglenoid Peranema trichophorum uses activation of the photoreceptor rhodopsin to control the probability of its curling behavior. ...