In Vivo Evaluation Articles & Analysis
14 articles found
However, the monitoring and detection of CAR-T cells in vivo remain a challenge in the evaluation of treatment efficacy. In this regard, the development of innovative tools and technologies such as in situ hybridization (ISH) probes has provided researchers with a powerful means to visualize and detect specific nucleic acids within cells or tissues. ...
Posterolateral Rabbit Spinal Fusion Study I. Introduction Autologous bone has long been the gold standard for bone graft substitute in spinal fusion procedures. The limited supply and morbidity associated with using autologous graft material led to the development of alternative bone grafting materials. Bioactive glass has a long history of biomedical use and has been shown to facilitate mineral ...
Furthermore, the nanoformulation platform includes in vitro and in vivo testing capabilities to evaluate the efficacy, safety, and stability of the nanoformulations. In vitro studies involve using cell cultures to test the drug release and cytotoxicity, while in vivo studies involve animal models to assess the biodistribution, pharmacokinetics, ...
It was assumed that the oxidation of unsaturated lipids in lyophilized LNPs led to the loss of transfection efficiency in the stored process because the degree of lipid unsaturated has a positive effect on LNP transfection. Finally, the team evaluated the in vitro and in vivo effects of the AA3-DLin mRNA COVID-19 vaccine. ...
To be more specific, fluorescent peptides are frequently used as signal peptides for in vivo biomedical imaging, protein binding, and localization studies for instance. ...
In-vivo Evaluation Of A Novel Surgical Heart Valve Prosthesis Designed To Be Durable, Anticoagulant-free And Silent. ...
Due to a lack of robust in vivo gut models, animal studies are generally required to evaluate gut toxicity. ...
In the current study, an in vitro experiment and an in vivo pig bioassay were conducted to evaluate the ability of a fat-based anti-pathogenic product to mitigate or inactivate PRRSV present in feed.The product used in the test was R2 from Feed Energy Company. ...
Our lead molecule exhibited no effect on the synthesis, processing, and secretion of PCSK9 either in the cells or into the media. In vivo pharmacological evaluation revealed that subcutaneous injection of 3 mg/kg of this antagonist resulted in a 25% reduction in LDL-C levels in mice fed a high fat/high cholesterol diet. ...
In animal studies, intraperitoneal (IP) injection of these compounds administered alone resulted in more than 20% reduction in LDL-C in mice fed a high fat/high cholesterol diet and over 40% reduction in LDL-C if administered in combination with atorvastatin. In vivo pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of these compounds demonstrated that ...
The aim to reduce the number of animals in experiments has highlighted the need to develop and validate non‐animal methods as alternatives to bioaccumulation studies using fish. The present study details a novel 3‐tier approach to develop a list of reference compounds to aid this process. The approach was based on: 1) inclusion of relevant chemical classes supported by high‐quality in vivo ...
Nanoconjugates have matured from simple devices to multifunctional, biodegradable, non–toxic and non–immunogenic constructs, capable of delivering synergistically functioning drugs in vivo. The present study evaluates the efficacy of drug polymer self folding nano–conjugates of pectin–cisplatin to enhance blood circulating levels of cisplatin. ...
In this article, a premixed acidic CPC has been compared to a conventional water mixed brushite cement to evaluate whether the premixed concept affects the biological response. The cements were evaluated regarding the pH-variation in simulated body fluid (SBF). Further, the biocompatibility of the cement with human mesenchymal stem cells (MSC) was studied in ...
Division of Neuroradiology, Department of Radiology University of Pennsylvania Hospital, Philadelphia, PA Purpose MR imaging is presumed hazardous in many patients with retained bullets, shot, and some aneurysm clips. Even though most bullets 1 and aneurysm clips are safe to scan, radiologists should be hesitant to perform MR in patients with metal when the composition is unknown. The purpose of ...