In Vivo Performance Articles & Analysis
5 articles found
In many cases, their relatively large molecular weight (usually > 1000 Da) may affect oral bioavailability, solubility, and/or in vivo pharmacokinetic properties (not conforming to the Lipinski's Rule of Five). ...
However, these perfused, vascular artificial pancreata were not successful in vivo, in part because of high rates of thrombosis of the synthetic materials used for the vascular conduit. ...
The AD-induced in vivo mouse model was performed as previously described with minor modifications (Kang et al., 2015). ...
We previously reported substantial differences in WF metabolism among avian species, however the actual in vivo pharmacokinetics have yet to be elucidated, even in the chicken. In the present study, we sought to provide an in‐depth characterization of WF metabolism in birds using in vivo and in vitro approaches. We performed a kinetic analysis of ...
Nanoconjugates have matured from simple devices to multifunctional, biodegradable, non–toxic and non–immunogenic constructs, capable of delivering synergistically functioning drugs in vivo. The present study evaluates the efficacy of drug polymer self folding nano–conjugates of pectin–cisplatin to enhance blood circulating levels of cisplatin. ...