In Vivo Response Articles & Analysis
7 articles found
It focuses on the relationship between drug concentration at the site of action and the resulting therapeutic or toxic response. In vivo PD studies allow for the observation of how a drug modulates biological pathways, providing insight into its potency, efficacy, and potential side effects. ...
Posterolateral Rabbit Spinal Fusion Study I. Introduction Autologous bone has long been the gold standard for bone graft substitute in spinal fusion procedures. The limited supply and morbidity associated with using autologous graft material led to the development of alternative bone grafting materials. Bioactive glass has a long history of biomedical use and has been shown to facilitate mineral ...
Adjuvants are non-specific immune enhancers that enhance or alter the type of immune response to an antigen. Adjuvants can help antigens induce long-term effective specific immune responses in vivo, leading to higher vaccine efficacy and prolonged protection from immune responses. ...
IL-2 regulates innate immune cells In humans, monocytes express IL-2R under the stimulation of IFN-γ, but only activated monocytes can bind with IL-2. During the inflammatory response, the expression of IL-2R will affect macrophage differentiation, limiting T cell proliferation and function. ...
Both current in vitro and in vivo models used in the development of candidate therapies for the treatment of intestinal diseases have severe limitations. ...
While in vitro testing methods have been developed to screen chemicals for endocrine disruption, extrapolation of in vitro response to in vivo action shows inconsistent accuracy. We describe here our tissue co‐culture of the fathead minnow (Pimephales promelas) HPG axis and liver (HPG‐L) as a tissue explant model that mimics in vivo results. ...
As a representative species of nematodes, Caenorhabditis elegans is an attractive animal model for evaluating ecotoxicological effects and intrinsic mechanisms of stress response in vivo. To acquire a better knowledge of environmental effects of bisphenol A (BPA), ecotoxicological evaluations were conducted using C. elegans upon the physiological (growth, ...