Insulin Induced Articles & Analysis
4 articles found
Obesity is a major risk factor for diabetes and leads to insulin resistance that often precedes diabetes. Currently, genome-wide association studies (GWAS) have identified more than 80 diabetes susceptibility loci, and an increasing number of mutations and variants have been identified in monogenic forms of diabetes, such as young adult-onset diabetes (MODY). ...
The main mechanisms by which ceramide regulates the development of obesity and related diseases are as follows: ceramide inhibits insulin signaling and hinders glucose metabolism; induces apoptosis; impairs mitochondrial function and induces mitochondrial autophagy. ...
Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated lipid peroxidation with further development of atherosclerotic alterations and diabetes. ...
Previous studies showed that SKIP negatively regulates insulin-induced phosphatidylinositol 3-kinase signaling (Ijuin and Takenawa, Mol. ...