Insulin Receptor Articles & Analysis
4 articles found
These drugs can be classified into insulin injections and oral antidiabetic medications. Commonly used oral antidiabetic drugs in clinical practice include biguanides (such as metformin), sulfonylurea insulin secretagogues (e.g., glimepiride, glipizide, gliclazide), non-sulfonylurea insulin secretagogues (e.g., repaglinide, nateglinide), ...
PiT1, initially identified as retrovirus receptor, is a transmembrane protein of the sodium-phosphate co-transporter family. PiT1 also has independent functions of its role as a phosphate transporter, notably on cell proliferation, adhesion or apoptosis. These observations suggest that interactions of PiT1 with other molecular partners may impact not only the homeostasis of inorganic phosphate, ...
Previously, we demonstrated that SRSF3 regulates splicing of the insulin receptor gene (INSR) (8) and plays an important role in hepatocyte differentiation and hepatic glucose and lipid metabolism (9). ...
Importantly, the defect in mTORC2 activity in these cells can be separated from effects on mTORC1 signaling and known feedback mechanisms affecting insulin receptor substrate-1 and phosphatidylinositol 3-kinase. Our data also suggest that the TSC1-TSC2 complex positively regulates mTORC2 in a manner independent of its GTPase-activating protein activity toward ...