Intestinal Development Articles & Analysis
12 articles found
Trillions of microorganisms live in the gastrointestinal tract, far outnumbering the body's own cells. The intestinal flora is involved in many physiological and pathological processes in the host, including digestion and absorption of food, metabolism of certain nutrients and pharmaceutical compounds, development of host immunity, intestinal ...
Meanwhile, as an important signaling molecule, bile acids can activate the relevant receptors to maintain the homeostasis of hepatic glucose and lipid metabolism, and interact with gut bacteria to regulate the development of the intestine and the inflammatory response of the body. ...
Main research directions of intestinal microorganisms at present are as follow: i. Differences in intestinal flora between disease group and healthy group. ii. Study the intestinal flora of drug or dietary intervention groups. iii. Intestinal flora of the same population in different growth stages. iv. Study the ...
Primary bile acids are secreted into the intestine and undergo 7α dehydroxylation by intestinal bacteria to form secondary bile acids. ...
Both current in vitro and in vivo models used in the development of candidate therapies for the treatment of intestinal diseases have severe limitations. RepliGut®, an in vitro human intestinal epithelial stem cell model, addresses many of these issues and has significant potential to reduce the time and cost of drug ...
Intestinal inflammatory diseases are highly complex, which has thus far prevented development of an effective in vitro disease model. ...
Gene-Editing Opportunities for RepliGut® Models Altis Biosystems has developed RepliGut®, a next-generation commercial intestinal tissue model platform for in vitro testing during drug development and for basic science applications. The RepliGut® platform produces a polarized monolayer of human intestinal stem and ...
Organ-on-a-chip models are the closest in vitro options, but they still have many limitations. More efficient development of drugs with attractive side effect profiles requires robust, easy-to-use, cost-effective in vitro gut models that are physiologically representative of the human intestinal tract and thus predictive of in vivo behavior. ...
To improve current bioaccumulation assessment methods, a methodology is developed, applied and investigated for measuring in vivo biotransformation rates of hydrophobic organic substances in the body (soma) and gastro‐intestinal tract of the fish. ...
Three-dimensional (3-D) tissue culture of human intestinal cells has shown promise in developing an infectivity assay, but reproducibility, even within a single laboratory, remains problematic. ...
These NC were loaded with multi functional anti cancer bovine lactoferrin (Lf), a natural milk based protein, for improvement of intestinal absorption, in order to develop a novel platform to carry anti cancer protein and/or peptides for oral therapy. ...
Mice carrying Apc mutations in their germ line (ApcMin) develop intestinal adenomas. Here, the crossing of ApcMin with cyclin D1–/– mice reduced the intestinal tumor number in animals genetically heterozygous or nullizygous for cyclin D1. Decreased tumor number in the duodenum, intestines, and colons of ApcMin/cyclin D1+/– mice ...