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Kidney Injury Articles & Analysis
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Hey everyone in the kidney community—whether you're battling IgA nephropathy (IgAN) yourself, supporting a loved one, or just here to learn—let's talk about something that's got me genuinely excited. For years, living with IgAN felt like a waiting game: watching your kidneys slowly decline, relying on blood pressure meds, and hoping dialysis or a transplant wasn't around the corner. ...
Hello, and welcome back to the Colorful Researcher’s blog. In our last blog, Peter discussed how AI is accelerating the drug discovery process and putting pressure on chemists, who must find ways of developing these potential drugs for subsequent testing or production. In his post, Peter explained how small instruments like BUCHI’s Glass Oven G-300 are great for working with small ...
ByBUCHI
Podocytes are specialized epithelial cells located in the kidneys, playing a crucial role in the filtration barrier of the glomerulus. ...
The human brain has long been regarded as one of the most enigmatic subjects in both medicine and science, captivating interest since ancient times. Its intricate architecture and advanced functionalities continue to inspire awe. However, it is through the lens of contemporary medical technology that we can begin to uncover the secrets within the brain, revealing the intricate structures nestled ...
Inflammatory effectors are key cytokines driving major clinical symptoms, like INF-γ inducing fever and hematopoiesis, TNF-α causing fever and depression, and IL-6 contributing to fever, acute kidney injury, and NK cell dysfunction. Inflammation initiation factors involve virus recognition by macrophage pattern receptors, triggering inflammasome ...
GLP-1 agonists and SGLT-2 inhibitors in combination with or without metformin (as required for glycemic management) have also been recommended by multiple guidelines as appropriate initial treatment for type 2 diabetes patients with atherosclerotic cardiovascular disease (ASCVD) or those at high risk for ASCVD, heart failure and/or chronic kidney disease. So, can the ...
The spinal cord is to relay messages between the brain and the rest of the boy. When spinal cord injury happens the body may lose some essential functions if the nerves can’t communicate with the brain. Inadequate bladder management of spinal cord injury (SCI) results in medical complications, psychological stress and even mortality. Frequent leakage of urine causes soiling of clothes ...
Tetrahydrocurcumin (THC), as the most active and main metabolite produced in the metabolism of curcumin in vivo, can be isolated from the cytoplasm of the small intestine and liver after curcumin administration in human or mouse. Tetrahydrocurcumin can effectively inhibit tyrosinase, inhibit the generation of Oxygen Free Radicals and scavenge the formed free radicals. It has obvious antioxidant ...
Urine E-cadherin was supposed to be a marker for early detection of kidney injury in diabetic patients. In Sun’s research, label-free quantification was applied to systematically compare the protein profiling in saliva and serum exosomes from healthy subjects and lung cancer patients, and potential candidates were discovered as biomarkers for lung cancer. ...
Mice have long served as the species of interest for biomedical research thanks to their genetic, physiological, and anatomical similarity to humans. Mice kidney samples are used to study renal biology covering topics such as acute kidney injury to chronic kidney disease, both of which are extremely useful for better ...
Annotations Kidney toxicity is a significant side-effect withGal-3 plays an essential role in kidney fibrosis and renal failure, and it is one of the critical factors for renal injury Inhibition of Gal-3, mediated by MCP, antagonized the pro-apoptotic (cell death) effects. ...
Abstract Purpose: We evaluated Galectin-3 (Gal-3) as a potential early biomarker of acute kidney disease (AKI), and the effect of Gal-3 inhibition by modified citrus pectin (P-MCP) on renal ischemia/reperfusion (I/R) induced AKI. ...
This, in turn, compromises a hospital’s antimicrobial stewardship efforts and increases the risk of patients experiencing antibiotic-associated complications like adverse drug events, multidrug-resistant organism infections, C. difficile, and acute kidney injury. Currently, the national benchmark for acceptable contamination rates sits at a too-high 3 ...
Abstract Background: Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). ...
Background: There are an estimated 300,000 deaths from acute kidney injury (AKI) annually in the U.S.1 A mountain of growing clinical literature has shown that hourly urine output (UO) monitoring may lead to earlier recognition of AKI and better fluid management, thus improving outcomes.2 However, there are multiple obstacles preventing nurses from getting ...
Annotations Acute kidney injury (AKI) is recognized as a potential risk factor for future cardiovascular events, especially heart failure. ...
Google DeepMind recently published a paper in Nature that shared how their predictive algorithm can detect Acute Kidney Injury (AKI) up to 48 hours in advance. Acute Kidney Injury is the biggest problem you have never heard of. In the US, 1 in 5 hospitalized adults gets Acute Kidney Injury, ...
Upset stomach, heartburn, diarrhea? There are few symptoms as disruptive to your daily life as ones that originate in the digestive system. And if you’re struggling with any of these symptoms, you know exactly how difficult they are to get rid of for good. Doctors recommend a variety of treatments, but there are three biggies they suggest most often for patients who are dealing with both ...
Annotations Preoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft surgery and/or valve. Patients in the highest third of Gal-3 levels had 2.95-greater odds of developing KDIGO Stage 2 or 3 (p < 0.001) and 1.71-increased odds of developing KDIGO Stage 1 (p = 0.001), compared to the lowest third. Elevated preoperative Gal-3 levels significantly ...
Chronic administration to Wistar rats of Mild Silver Protein (MSP) to a dose of 222 mg Ag/kg/day in the drinking water for six months showed that the MSP produces argyria, with histopathological lesions in the kidney, the organ where silver accumulates. The histopathology of the kidney showed capillary damage, with alteration of the vascular wall, increased perivascular cellularity and area with ...