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Liver Injury Articles & Analysis

8 articles found

Preclinical Models of Non-Alcoholic Fatty Liver Disease

Preclinical Models of Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant public health concern, associated with obesity, insulin resistance, and a spectrum of metabolic disorders. ...

ByCreative Bioarray


What is FGL2?

What is FGL2?

As a protein molecule related to chronic inflammation and immune injury, FGL2 can also promote the occurrence and development of tumors. ...

ByCreative Diagnostics


Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

In parallel with the changes in biochemical and histological liver injury markers, the cecal levels of secondary bile acids (DCA and LCA) were also decreased by an MCD diet and increased by R. faecis treatment (Fig. 8g). ...

ByKoBioLabs


Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice

Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice

Graphical Abstract Keywords microbiome alcohol liver diseases roseburia fat liver diseases hepatitis occludin liver steatosis leaky gut Introduction Long-term excessive alcohol consumption is the most important risk factor for the development of alcohol-related liver diseases (ALDs), including alcoholic ...

ByKoBioLabs


	 Utilization of a 3D bioprinted liver tissue model to evaluate the antifibrotic effects of an ALK5 inhibitor in a TGFß-induced model of hepatic fibrosis

Utilization of a 3D bioprinted liver tissue model to evaluate the antifibrotic effects of an ALK5 inhibitor in a TGFß-induced model of hepatic fibrosis

Publication Summary: Compound induced chronic liver injury can lead to initiation of profibrotic processes resulting in sustained production of growth factors and profibrotic cytokines where inflammation, tissue remodeling and repair pathways are activated simultaneously to counteract the injury. ...

ByOrganovo Holdings Inc.


Long-term performance of implanted bioprinted human liver tissue in a mouse model of human alpha-1 antitrypsin deficiency

Long-term performance of implanted bioprinted human liver tissue in a mouse model of human alpha-1 antitrypsin deficiency

Publication Summary: Conventional cell therapy and tissue engineering approaches to treating liver diseases and injury are limited by low cell retention, poor engraftment, poor graft durability and complications including portal hypertension. Integration of next generation technologies such as 3D bioprinting is an essential step towards the clinical success of ...

ByOrganovo Holdings Inc.


A Suture-Based Liver Retraction Method for Laparoscopic Bariatric Procedures: Results From A Large Case Series

A Suture-Based Liver Retraction Method for Laparoscopic Bariatric Procedures: Results From A Large Case Series

Background In laparoscopic bariatric procedures, retraction of the left lobe of the liver is essential to visualize and operate on the stomach, esophagus, and other structures that lie beneath the liver. ...

ByFreeHold Surgical, LLC


Randomized controlled trial comparing three methods of liver retraction in laparoscopic Roux-en-Y gastric bypass

Randomized controlled trial comparing three methods of liver retraction in laparoscopic Roux-en-Y gastric bypass

Article Overview Traditional liver retractors require another wound for insertion, are bulky, and may cause iatrogenic liver injury. This study aimed to evaluate differences between three methods of liver retraction during laparoscopic Roux-en-Y Gastric bypass (LRYGB) and to compare novel liver retraction ...

ByFreeHold Surgical, LLC

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