Liver Metabolism Articles & Analysis
19 articles found
ADME stands for Absorption, Distribution, Metabolism, and Excretion, which are critical processes that determine the fate of a drug within the body. ...
Pharmacokinetics: The Journey of a Drug The pharmacokinetic profile of a drug describes its absorption, distribution, metabolism, and excretion (ADME) processes. These stages dictate how fast a drug acts, how long its effects last, and how it is eliminated from the body. ...
Despite its benefits, curcumin has a major drawback: it is poorly absorbed in the gastrointestinal tract and is quickly metabolized by the liver, leading to diminished effects. What is Liposomal Curcumin? ...
Pharmacokinetic characteristics are composed of and determined by drug absorption, distribution, metabolism and excretion. The structure, physiological properties and pharmacokinetic characteristics of monoclonal antibodies are different from those of traditional small molecule drugs. ...
Dysbiosis of the intestinal flora is associated with a variety of human metabolic diseases, such as obesity, diabetes mellitus, and nonalcoholic fatty liver disease. ...
Hepatocytes are the chief functional cells of the liver, responsible for the selective uptake, metabolism and excretion of most drugs. Cells for use in plate cultures or suspension assays represent a key tool for predicting properties such as hepatotoxicity, metabolism, and potential drug-drug interactions. Since these cells mimic the properties ...
Dysbiosis, an imbalance in gut microbial communities, has been linked to altered bile acid metabolism and, consequently, to diseases like non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes. ...
Functions of AMPK Once activated, AMPK regulates four major classes of metabolism in mammals: protein metabolism, lipid metabolism, sugar metabolism, and autophagy and mitochondrial homeostasis, encompassing almost the entire physiological metabolic activity of living organisms. AMPK can stop the ...
Bile acids are the main components of bile and are synthesized in the liver from cholesterol through a series of enzymatic reactions. Bile acids can be divided into free bile acids and conjugated bile acids according to their structures. ...
Vitamin B2: Promotes the metabolism of carbohydrates, fats and proteins, and helps to form antibodies and red blood cells and maintain cellular respiration. ...
They discovered that following early morning exercise, the liver demonstrated a considerable fatty acid metabolic response, with selective increases in fatty acid metabolites. ...
In humans and mammals, alcohol dehydrogenase and aldehyde dehydrogenase (ALDH) constitute the alcohol dehydrogenase system, which is involved in ethanol metabolism in vivo and is an important metabolic enzyme in humans and animals. ...
Osteoarticular disease: It can neutralize harmful acidic substances in the body and lower blood uric acid value to relieve gout and other bone and joint diseases. Liver protection: Hydrogen can remove the malignant free radicals produced by ethanol during metabolism, promote metabolism and protect the liver. ...
This wonder ingredient can help support two of the most important health concerns in the world, liver health and metabolic function" says Hagai Stadler, CEO of Algatech. Liver health is one of the most serious modern health issues todayfll. ...
ByAlgatech
Researchers have found NAFL in 40 to 80 percent of people who have type 2 diabetes and in 30 to 90 percent of people who are obese 01 Additionally, it is estimated that 1 in 4 people around the world have some sort of NAFL while in the U.S. up to 100 million people may have fatty livers [n]. Even though the above metabolic conditions contribute to having a fatty ...
ByAlgatech
Abstract Serine-rich splicing factor 3 (SRSF3) plays a critical role in liver function and its loss promotes chronic liver damage and regeneration. ...
The potential new medicines are for the treatment of methylmalonic acidemia (MMA) and propionic acidemia (PA), diseases with defective enzymes along the same metabolic pathway. These diseases are caused by a genetic defect that results in either too little or no production of a critical metabolic enzyme produced by liver cells, leading to ...
Parametric analysis of gene set enrichment revealed an important increase in the expression of genes related to drug metabolism and transport, liver metabolism, xenobiotic clearance, and xenobiotic metabolism after DMP and DCHP treatments, while these responses were less pronounced with MMP (the metabolite of DMP). ...
We previously reported substantial differences in WF metabolism among avian species, however the actual in vivo pharmacokinetics have yet to be elucidated, even in the chicken. In the present study, we sought to provide an in‐depth characterization of WF metabolism in birds using in vivo and in vitro approaches. We performed a kinetic analysis of WF ...