Lung Injury Articles & Analysis
7 articles found
ELANE, or neutrophil elastase (NE), is a serine protease stored in the azurophilic granules of neutrophils and is encoded by the ELANE gene on chromosome 19. It plays a pivotal role in the host defense system by degrading bacterial proteins, remodeling extracellular matrices, and shaping inflammatory responses. However, the same proteolytic activity that protects against pathogens can, when ...
What is CD73? CD73, also known as ecto-5′-nucleotidase, is a groundbreaking immunoinhibitory protein that assumes a pivotal role in tumor growth and metastasis. Its primary function revolves around converting extracellular ATP into immunosuppressive adenosine, working in tandem with CD39 within normal tissues to curtail excessive immune reactions. However, this mechanism is often hijacked ...
I was fortunate to receive the SOT Supplemental Training for Education Program (STEP) award. With this award, I traveled to Sapienza Università di Roma in Italy, to the laboratory of Dr. Rita Businaro for what was intended to be a three-month training period focused on mesenchymal stem cells (MSCs), cells that modulate immune response and tissue repair. Dr. Businaro is an expert in MSCs ...
After a lightning round of proposals and reviews, an international team of scientists led by Dr. Camillo Ricordi was granted immediate FDA authorization for a 24-patient clinical trial to test the safety and exploratory efficacy of umbilical cord-derived mesenchymal stem cells (UC-MSCs) to block the life-threatening lung inflammation that accompanies severe cases of COVID-19. The therapy uses ...
Clinical analysis of 25 novel coronavirus pneumonia deaths:asphyxia due to pulmonary mucus Pengpai news reporter Wu Yi Pengpai news ,February 29 On February 25, MedRxiv published a paper from Wuhan University People's Hospital, Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China. The ...
Abstract Background: Noninvasive ventilation (NIV) via helmet or total facemask is an option for managing patients with respiratory infections in respiratory failure. However, the risk of nosocomial infection is unknown. Methods: We examined exhaled air dispersion during NIV using a human patient simulator reclined at 45° in a negative pressure room with 12 air changes/h by two ...
Abstract Background: As part of our influenza pandemic preparedness, we studied the exhaled air dispersion distances and directions through two different face masks (Respironics; Murrysville, PA) attached to a human-patient simulator (HPS) during noninvasive positive-pressure ventilation (NPPV) in an isolation room with pressure of -5 Pa. Methods: The HPS was positioned at 45 degrees on ...