Lung Mechanic Articles & Analysis: Older
5 articles found
Idiopathic pulmonary fibrosis (IPF) is a devasting lung disease characterized by progressive scarring of lung tissue. As fibrosis develops, patients experience worsening shortness of breath, reduced lung capacity and ultimately respiratory failure. Current therapies for IPF rely on oral administration of pirfenidone and nintedanib, two FDA-approved drugs that slow disease progression. While ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. ...
Pulmonary function tests evaluate lung function and diagnose respiratory conditions. Two critical tests of pulmonary assessment are spirometry and the measurement of diffusing capacity of the lungs for carbon monoxide (DLCO). While spirometry evaluates how effectively the lungs inhale and exhale air, DLCO assesses the lungs' ...
In a recent Nature publication by Schappe,M (2024), researchers have revealed a fascinating aspect of respiratory physiology: the role of sensory neurons in guarding against airway obstruction and orchestrating crucial reflexes to maintain respiratory function. The study explores the intricate neural pathways involved in detecting and responding to airway closure. By characterizing a ...
Examples of applications are given in the context of the acute respiratory distress syndrome (ARDS), an inflammatory disease of the lung triggered by a massive arrest of white blood cells in the lung microvasculature. ...