Lung Mechanic Articles & Analysis
12 news found
A recent study by Rojas-Ruiz et al (2025) utilizes SCIREQ’s innovative physioLens (ex vivo) and flexiVent (in vivo) platforms to shed light on the interplay between lung tissue compliance and methacholine response, offering new insights into the mechanisms driving asthma pathology. ...
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by progressive scarring of the lungs, which severely impairs lung function over time. Developing effective treatments for IPF has been a challenge for the medical community, as the mechanisms driving this disease are complex and not fully understood. ...
Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) are major global health threats. Their interaction worsens disease severity, as HIV reduces CD4+ T cells, making individuals more vulnerable to TB. Despite progress, an effective animal model that mimics human immune response during HIV/TB co-infection has been lacking, hindering treatment and vaccine development. Bohorguez et al. ...
The rise of antibiotic-resistant bacteria has driven renewed interest in alternative treatments, including phage therapy. A recent study by Yang, F., et al (2024) explores the potential of bacteriophage therapy for treating multi-drug resistant Mycobacterium tuberculosis (Mtb) infections using humanized mouse models. This study highlights the efficacy of phage DS6A in reducing Mtb load ...
In the realm of pulmonary research, the search to understand complex lung conditions has led to the development of various animal models. Among these, a new murine model from Tsijis et al stands out for its potential to investigate flow-induced pulmonary hypertension (PH) and compensatory lung growth (CLG). This blog outlines this innovative model, its significance, and the method of ...
Chan continued, “ECMO is a machine that pumps and oxygenates blood outside the body when a patient’s lungs are so diseased that mechanical ventilation fails. Without ECMO, these patients – often considered among the sickest in the ICU – would normally die. ...
Atkins will discuss the challenges of high-dose drug delivery to the lungs and highlight how Nob Hill Therapeutics' patented DryNeb™ addresses those issues. DryNeb provides a novel and efficient approach to achieving lung delivery via mechanical energy input to a static powder bed to facilitate more effective pulmonary delivery. ...
” “We are pleased that LTI-03 has passed this important safety milestone as we continue development”, said Brian Windsor, Ph.D., President and CEO of Lung Therapeutics. “We believe that the mechanism LTI-03 is unique among drugs in development for IPF, and we are excited to move LTI-03 into the next stage of clinical development in IPF ...
LTI-03 is being developed for the treatment of IPF. LTI-03 has a unique mechanism, one aspect of which involves inhibiting the formation of scar-like material in the lungs. More importantly, however, this mechanism also promotes protection of critical cells in the lungs which are believed to be vital in improving and restoring ...
Professor André Vincentelli, MD, Head of the Mechanical Circulatory Support and Transplantation Program at Lille University Hospital and a scientific partner of CorWave, commented, “CorWave continues its remarkable progress and reaches a major milestone towards clinical application with these 6-month real-time ...
ByCorWave
In the blood gas exchange in the lungs alveoli Carbon dioxide is released into and Oxygen is taken up from the inhaled air. This exchange also applies to volatile metabolites that are produced in the body or in the lungs directly. By this mechanism researchers are trying to detect volatile biomarkers in exhaled breath that are indicative for a ...
tiakis BIOTECH AG today announced the publication of research results by Alcazar et al. from Stanford University on a new mechanism by which Elafin rescues lung cell survival in the lung of newborn mice subjected to mechanical ventilation. ...