Metabolic Demand Articles & Analysis
2 articles found
Native islets require high levels of oxygen to survive: islets utilize 5%–20% of the oxygen provided to the pancreas, despite making up only 1%–2% of pancreatic mass. Given the high metabolic demands of islets, it is evident that islet transplant strategies require attention to oxygenation to achieve sufficient islet survival. ...
Lactate is usually produced and released into the bloodstream as a result of anaerobic cell metabolism (when oxygen demand is higher than supply) and present at a concentration of 1 – 1.5 mmol/L, however when there is insufficient oxygen to allow activity in a patient’s cells, lactate levels become elevated to above 2 mmol/L. ...