Refine by
Metastasis Articles & Analysis: Older
36 articles found
By labeling cancer cells with a fluorescent or luminescent reporter gene, scientists can track tumor growth and metastasis both in vitro and in vivo. This ability to visualize cellular processes in real time provides insights into the progression of diseases and the effectiveness of therapeutic agents. ...
Many studies have demonstrated that miRNA mimics can suppress tumor growth and metastasis by restoring the expression of tumor-suppressor genes. The development of miRNA-based therapies has garnered significant interest, with some products currently in clinical trials. ...
In terms of cancer research, zebrafish allow scientists to study processes such as tumor formation, migration, and metastasis, and to flexibly identify optimal molecules or/and known drugs (repositioning) to treat each different tumor ...
For example, in cancer, abnormal glycosylation patterns may lead to changes in protein function, thereby promoting tumor growth and metastasis. The detection of glycosylation sites provides new avenues for early diagnosis and treatment of diseases. ...
Co-culture cell models can emulate a variety of pathological conditions such as different stages of tumor invasion and metastasis, and identify of stromal components associated with pathological ...
This approach can also help detect metastasis early. Omics Analysis for Brain Tumors Similarly, by integrating data from multiple omics layers, researchers can understand the complex biology of tumors better and develop targeted therapies. ...
It's been implicated in various cancers, where it can contribute to uncontrolled growth and metastasis. In the tumor microenvironment, TNC protein can even manipulate the immune system, shielding cancer cells from attack. ...
Moreover, to further explore the mechanism of PC occurrence, development, invasion, and metastasis, Alfa Cytology independently developed PC model construction services, dedicated to offering different preclinical cell models for PC research. ...
Over time, these cancerous cells may foray into nearby tissues and ultimately spread to other areas of the body through the lymphatic system or bloodstream, and this process is called metastasis. Some crucial factors can contribute to the development of breast cancer, including gene mutations, hormonal influences, lifestyle choices, and environmental exposures. ...
Therefore, therapeutic RDCs can be used to kill cancer cells or alleviate pain in cancer bone metastasis treatment. Typical therapeutic isotopes include I-131, Lu-177, Y-90, and Ra-223. ...
This loss of CDH1 function disrupts cell adhesion and promotes tumor invasion and metastasis. CDH1 loss is particularly significant in epithelial cancers, such as breast, gastric, and colorectal cancers. ...
Fucoidan derivatives have been shown to inhibit tumor cell growth, induce apoptosis, and suppress tumor metastasis. Additionally, marine polysaccharides exhibit antioxidant, anti-inflammatory, anticoagulant, and immunomodulatory activities, making them highly valuable for drug discovery and development. l Drug Delivery System In drug delivery systems, marine polysaccharides can ...
CD73 Expression and Its Impact on Tumor Cells CD73 is found at higher expression levels in the majority of human solid tumors, and its presence is closely linked to tumor invasiveness and metastasis[15]. Research[16] has confirmed that the extracellular adenosine produced by CD73 on tumor cells plays a significant role in immune evasion, facilitating tumor growth and ...
Two important stages of cancer development are tissue infiltration and metastasis, both of which are also regulated by NF-κB-dependent genes, including matrix metalloproteinases, urokinase fibrinolytic element activator, and interleukin IL-8. ...
Its reduced expression can contribute to tumor progression and metastasis. CADM1 and Ovarian Cancer In ovarian cancer, CADM1 downregulation has been observed in certain subtypes. ...
In the PI3K-AKT signaling pathway, Nectin-4 promotes cancer cell proliferation and metastasis by activating WNT-β-catenin and Rac small G proteins. Nectin-4 also interacts with the tyrosine kinase receptor ERBB2, promoting its activation and stimulating the PI3K-AKT signaling pathway. ...
So far, studies have found that it has anti-metastasis and anticancer activities, antioxidant, free radical scavenging, hypoglycemic, hypolipidemic and other pharmacological activities, and a large number of experimental results show that its biological activities are better than curcumin, such as antioxidant chloroquine-induced kidney damage, antioxidant azo-methane induced ...
Supplementation of mesothelin or MPF to stimulate the growth of MSLN knockout mice promotes lung cancer growth, which supports the role of mesothelin in tumor cell adhesion, migration and metastasis. The Role of Mesothelin in Cancer Mesothelin is expressed in many solid tumors, most commonly in mesothelioma, epithelial ovarian and pancreatic cancers, but also in lung and uterine ...
Mesothelioma and ovarian cancer have the highest expression of mesothelin, and higher expression is associated with advanced tumor stage and higher metastasis rate. In stage IV colorectal cancer, high mesothelin expression is directly associated with chemotherapy resistance, aggressiveness, and poor prognosis. ...
On May 23, 2020, FDA approved Brigatinib as a first-line treatment for patients with metastatic NSCLC who are genetically ALK-positive. 5.Ensartinib Ensartinib is featured with high efficiency, low toxicity, and outstanding effect on brain metastasis. It is a new type of potent, highly selective second-generation ALK inhibitor. ...