Mitochondrial Apoptosis Articles & Analysis
2 articles found
The main mechanisms by which ceramide regulates the development of obesity and related diseases are as follows: ceramide inhibits insulin signaling and hinders glucose metabolism; induces apoptosis; impairs mitochondrial function and induces mitochondrial autophagy. Ceramide and Cardiovascular Diseases Elevated ceramide concentrations can lead ...
Constitutively active tyrosine kinases promote leukemogenesis by increasing cell proliferation and inhibiting apoptosis. However, mechanisms underlying apoptotic inhibition have not been fully elucidated. In many settings, apoptosis occurs by mitochondrial cytochrome c release, which nucleates the Apaf-1/caspase-9 apoptosome. ...