Mitochondrial Function Articles & Analysis
10 articles found
This modification system plays a crucial role in cellular biological processes such as tumor metabolism and immune regulation while also shaping the tumor microenvironment through control of translation efficiency and mitochondrial function along with tRNA fragment generation. Through its impact on translation efficiency and mitochondrial ...
Since then, the BCL2 protein has become a key target in oncology and molecular biology. Functions and Roles in the Body Proteins encoded by the BCL2 gene family function primarily at the mitochondrial membrane, where they regulate the release of cytochrome c—a crucial step in the apoptotic process. ...
Consequently, NAD/NADH analysis is a cornerstone of metabolomics research, providing critical insights into metabolic health, mitochondrial function, and disease pathogenesis. In this article, we will discuss the science behind NAD/NADH, their role in metabolism, and the significance of precise NAD/NADH analysis in various fields of biology and medicine. ...
Mitochondria play a key role in maintaining cellular health and viability, and their dysfunction not only contributes to the development of many human diseases such as neurodegenerative diseases, cardiovascular diseases, obesity and type II diabetes, but also reduces oocyte quality and early embryonic development in animals. Mitochondrial function is dependent on ...
Ceramide is synthesized and secreted by lamellar vesicles, which together with cholesterol (25%) and free fatty acids (15%) constitute the intercellular lipids (ceramide 50%) involved in maintaining the skin barrier function. It also has various physiological and pharmacological functions, such as regulation of cellular immunity, delaying aging, and antitumor. ...
Sophisticated bioinformatics tools are able to reveal mitochondrial function and its contribution to cellular health and disease. Abnormal expression of mitochondrial proteins is the main cause of their dysfunction. Mitochondrial proteomics analyzes the dynamic changes of protein composition, expression level and modification ...
More than just components of cell membranes and energy storage substances, lipids can perform a variety of important biological functions in life activities. The structural diversity of lipids endows them with a variety of important biological functions: (1) they constitute an important component of the cell membrane. ...
Bisphenol A acts as an endocrine disruptor, affects animal reproductive success in vivo, and affects sperm functions in vitro at environmentally relevant concentrations leading to reduction in sperm motility and fertilizing ability in fish. The effect of in vitro BPA on avian sperm functions has not been explored. We tested the effect of environmentally relevant concentrations of BPA (0, 0.18, ...
We also found that mutants deleted for components of the mitochondrial retrograde signaling pathway can tolerate prolonged exposure to CO but not to N2. We conclude that the cellular response to anoxia is dependent on whether the anoxic gas is an oxygen mimetic and that the mitochondrial retrograde signaling pathway is functionally important ...
We describe phylogenetic and functional studies of three septins in the free-living ciliate Tetrahymena thermophila. ...