Nk Cell Therapy Articles & Analysis
4 articles found
B7-H3 is expressed in non-immune cells such as synovial cells, osteoblasts, endothelial cells, and can also be induced on the surface of immune cells, including dendritic cells, monocytes, and B cells. ...
In addition, mesothelin binding to CA125/MUC16 also triggers the expression of MMP-7 through the p38 MAPK pathway in pancreatic ductal adenocarcinoma. In addition, pancreatic cancer cell lines overexpressing mesothelin significantly increase their proliferation and accelerate the cell cycle process compared with mesothelin-silencing cell lines. ...
In hematological malignancies, complete response rates to CAR-T cells can exceed 80%. These responses are often durable in nature and have attracted considerable excitement and investment in the development of cell therapies for an expanded range of indications, particularly in solid tumors. ...
Chimeric antigen receptor T-cells (CAR-T) are one of the first clinically approved therapies to take full advantage of the most significant advancements in immunology and genetic engineering. ...