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Moreover, lipidomic shifts can also reveal insights into metabolic conditions such as obesity, diabetes, and neurodegenerative diseases. For instance, certain lipid species found in exosomes may indicate disrupted signaling pathways or abnormal cellular function, providing opportunities for therapeutic intervention. ...
This function is particularly important in the context of metabolic disorders such as obesity and type 2 diabetes. Impaired endothelial function in muscle microvasculature can lead to reduced insulin sensitivity and glucose uptake, further exacerbating metabolic dysregulation. ...
Disturbances in metabolic pathways can lead to many common human diseases such as cancer, diabetes, obesity, hypoglycemia, hypolipidemia, phenylketonuria, neurodegeneration, etc. ...
Dysbiosis of the intestinal flora is associated with a variety of human metabolic diseases, such as obesity, diabetes mellitus, and nonalcoholic fatty liver disease. Regulation of lipoprotein metabolism by intestinal flora The intestine is not only a site of lipid digestion and absorption, but also a place where a large number of microorganisms reside. ...
Dysbiosis, an imbalance in gut microbial communities, has been linked to altered bile acid metabolism and, consequently, to diseases like non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes. A landmark study conducted in collaboration with Creative Proteomics investigated the bidirectional relationship between bile acids and the gut microbiota in NAFLD. ...
Diabetes, specifically Type 1 and Type 2 Diabetes Mellitus, remains one of the most commonly encountered metabolic diseases worldwide. ...
More than 95 percent of people with diabetes have type 2 diabetes (formerly known as non-insulin-dependent diabetes or adult-onset diabetes), which is characterized by the body's abnormal use of insulin that affects the body's use of glucose for energy, mainly due to obesity, physical inactivity and genetics. 2. ...
In addition, our previous study also found that tetrahydrocurcumin has a good therapeutic effect on metabolic syndrome, obesity type 2 diabetes, hypertension, insulin resistance syndrome and other related diseases, and has a wide range of application prospects. 1.Hypoglycemic Effect Murugan P et al. induced type 2 diabetes mouse model with ...
This type of inflammation specifically results from noncardiac metabolic risk factors, including obesity, diabetes, anemia, hypertension, chronic obstructive pulmonary disease (COPD), auto-immune diseases, and renal insufficiency. [4] Other Key Differences Between HFpEF and HFrEF: Risk Factors, Diagnosis, and Treatment Risk factors Molecular and cellular ...
HFpEF patients are likely to have a high prevalence of cardiovascular and non-cardiovascular comorbidities, such as obesity, metabolic syndrome, diabetes mellitus type 2, salt-sensitive hypertension, atrial fibrillation (AF), chronic obstructive pulmonary disease, anaemia, and renal dysfunction.[6.7,8] As life expectancy and comorbidity rates rise, the ...
Friedlander's lab has also shown that Moreover, PiT1-deficient mice were protected against high-fat-diet-induced obesity and ...
Physical signs of heart failure (HF) (such as elevated jugular venous pressure, pulmonary rales, and lower extremity edema) may or may not be present. [9] A history of atrial fibrillation (AF), obesity, and diabetes all increase the likelihood of HFpEF. [10] (Table 1). ...
BioLingus will position these products in the “epidemic” markets of obesity and type II diabetes : More than 400 MM people suffer from diabetes today. ...
Mitochondria play a key role in maintaining cellular health and viability, and their dysfunction not only contributes to the development of many human diseases such as neurodegenerative diseases, cardiovascular diseases, obesity and type II diabetes, but also reduces oocyte quality and early embryonic development in animals. ...
Obesity is a major risk factor for diabetes and leads to insulin resistance that often precedes diabetes. ...
Research Achievements of Human Microbiome In recent years, with the continuous research on the human microbiome, gut microbes have been found to be closely related to a variety of human diseases, including not only digestive tract diseases such as colitis and colon cancer (these digestive tract diseases, flora, and digestive tract are in direct contact), but also metabolic diseases such as ...
Affecting eight to 10 million people in the U.S., and 200 million people worldwide[i], PAD’s primary risk factors include obesity, high cholesterol, hypertension, diabetes and tobacco use. The prevalence of PAD rises with age, from five percent at age 60 to 20 percent at age 80. ...
The increasing incidence of peripheral artery disease (PAD) is occurring globally as populations age and rates of diabetes, obesity, and renal disease increase.1-3 Although most of these patients have no symptoms, when the disease progresses to its most advanced form, chronic limb-threatening ischemia (CLTI), there is a significant risk for limb loss. ...
It is commonly associated with obesity, metabolic syndrome, type 2 diabetes, and polycystic ovary syndrome. ...
ByAlgatech
NAFL is more common in people who have certain conditions such as obesity and type 2 diabetes. Researchers have found NAFL in 40 to 80 percent of people who have type 2 diabetes and in 30 to 90 percent of people who are obese 01 Additionally, it is estimated that 1 in 4 people around the world have some sort of NAFL while in the ...
ByAlgatech