Pain Including Neuropathic Pain Articles & Analysis
12 articles found
This enzymatic activity enables ENPP2 to control diverse cellular functions, including proliferation, migration, adhesion, and survival. LPA interacts with G protein-coupled receptors (LPA1–LPA6), activating downstream cascades such as PI3K-Akt, Rho, and MAPK, which regulate cytoskeletal remodeling, gene expression, and cellular motility. ...
What is diabetic neuropathy? The most common complication of diabetes is neuropathy, which is nerve damagecaused by high blood sugar. Most neuropathy affects the legs, hands and feet and usually presents as numbness, pain or tingling. Diabetic neuropathy can also seriously impact the heart, blood vessels, digestive system and the kidneys. Symptoms can range from mild discomfort to extreme pain. ...
The Relationship Between LncRNAs and Diseases Unlike other ncRNAs such as miRNAs, lncRNAs are large and complex. lncRNAs' molecular mechanisms mainly include (1) binding directly to DNA or transcription factors to achieve regulation of gene expression through translational processes; (2) targeting mRNAs, miRNAs or proteins to regulate post-translational stability and activity; ...
INTRODUCTION After a peripheral nerve injury, fast conducting large myelinated afferent A-bcta fiber transmission diminishes over time. On the other hand, firing of smaller pain transmitting fibers such as A-dclta and C-fibcrs is enhanced. This aberrant afferent neuronal behavior is thought to be one of the main neuronal mechanisms leading to development of chronic posttraumatic peripheral ...
Abstract Background. Peripheral nerve injury can result in the formation of neuroma/nerve entrapment, a persistent peripheral neuropathic pain state which is often refractory to invasive interventions or medications. Therefore, there is a need in the field of pain management to develop innovative noninvasive therapy in treating post-traumatic peripheral neuropathic pain states. A new ...
1. Tetrahydrocannabinol (THC) Tetrahydrocannabinol (THC) is an active ingredient in Nabiximols, a specific extract of Cannabis that was approved as a botanical drug in the United Kingdom since 2010 as a mouth spray for people with multiple sclerosis to reduce neuropathic pain, spasticity, overactive bladder, and other symptoms. Nabiximols (as Sativex) is available as a prescription drug in ...
My role as a Research Scientist is quite dynamic where my day-to-day duties can vary greatly from R&D projects to product manufacture, and from inventory and laboratory management roles to neuropathic pain preclinical trial designs. I have been heavily involved in the Regeneus pain project after Regeneus received an ARC Linkage Grant with ...
So, we have a non-opiate pain reliever for both somatic sensory pain and neuropathic pain. This is important because it is working to solve a huge unmet medical need — there is currently nothing else like this on the market, and we think we finally have one. ...
I have been a researcher in microbiology for over 30 years and in that time founded three successful biotech companies, including BTF, Regeneus, and Biopoint. My career began in the UK at the Centre for Applied Microbiology and Research at Porton Down where I conducted research into Legionnaires Disease. ...
Everyone at some time in their life has suffered from the throbbing, aching, and annoying pain of a headache. Headaches can be mild, or they can be severe and even debilitating. While most people experience a headache occasionally, others deal with recurrent head pain, sometimes experiencing headaches weekly, or even up to 15 or more times each month, as in the case of chronic ...
During this spring, the COVID-19 pandemic has dramatically changed every aspect of life. The business environment has changed not to mention the healthcare sector where the very foundations have been tested around the world. The news have been filled with corona topics and at times the pandemic has seemed to hide other alarming issues: for example, it has been reported in the US that ...
Believers and users of CBD extoll its benefits for inflammation, muscle soreness, pain, anxiety and a whole host of other things, including cancer. ...