Pathology Physiology Articles & Analysis
24 articles found
By bridging extracellular lipid cues with intracellular responses, ENPP2 functions as a critical mediator of both physiological homeostasis and pathological processes. Structural Insights and Catalytic Mechanism ENPP2’s function is tightly linked to its sophisticated structure. ...
Immortalized human podocytes represent a significant advancement in the field of renal research, offering scientists an unprecedented opportunity to study kidney function and pathology. These specialized cells play a crucial role in the filtration barrier of the kidneys, and their immortality allows for extended experimentation beyond the limitations of primary cell cultures. ...
The Role of Podocytes in Kidney Disease Recent research has highlighted the importance of podocytes in various renal pathologies. Conditions such as diabetic nephropathy, focal segmental glomerulosclerosis, and nephrotic syndrome are characterized by podocyte injury or loss. ...
These models can recapitulate aspects of human physiology, pathology, and behavior, making them indispensable in translational research. ...
Cytokines and growth factors are essential signaling molecules that play pivotal roles in immune regulation, inflammation, tissue repair, and numerous physiological and pathological processes. To comprehensively study these molecules, scientists often rely on high-throughput and sensitive technologies, among which Luminex Cytokine Panels have become a gold ...
The Mouse Luminex Cytokine Assay has emerged as a cutting-edge technology for high-throughput, sensitive, and accurate cytokine analysis, offering researchers unparalleled insights into immune function and pathology. The Importance of Cytokine Analysis in Mouse Models Cytokines and chemokines are small signaling proteins that mediate communication between immune cells. ...
Due to their crucial roles in physiological and pathological processes, nuclear receptors have emerged as significant targets for drug discovery and development. ...
Therefore, the detection of sialic acid proteins holds significant value in disease diagnosis, biomedical research and drug development.Biological Importance of Sialic Acid ProteinsSialic acid proteins play an indispensable role in many physiological and pathological processes. Under normal conditions, they participate in intercellular communication, regulation ...
Elastase is a powerful enzyme that plays a critical role in various biological processes, both in physiological and pathological contexts. It belongs to the family of serine proteases, which are enzymes characterized by a unique serine residue in their active site. ...
By studying the protein interaction network, it reveals the molecular mechanisms of various physiological and pathological processes in cells, providing new ideas for disease diagnosis and treatment. ...
Ubiquitination detection contributes to a better understanding of the role of ubiquitination in cellular physiological and pathological processes, particularly in studying protein degradation, signal transduction disorders, and molecular mechanisms associated with various diseases such as cancer and neurodegenerative diseases. ...
Introduction Cellular mechanisms driving cell death play a crucial role in various physiological and pathological processes. One such mechanism is apoptosis, a tightly regulated process vital for maintaining tissue homeostasis, development, and immune response. ...
The intestinal flora is involved in many physiological and pathological processes in the host, including digestion and absorption of food, metabolism of certain nutrients and pharmaceutical compounds, development of host immunity, intestinal inflammatory states, and more. ...
It contributes extensively to the understanding of the physiological function of ionic channels in health and disease. From exploring their roles in some neurological disorders, cardiovascular diseases to electrolyte imbalance—it's a resourceful tool. ...
The study of respiratory function and control of breathing is vital for understanding various physiological and pathological conditions. In preclinical research, gaining accurate and reliable data is essential to make meaningful discoveries and develop potential therapies. ...
Drug Discovery Platform IVS has become a leading developer of human 3D cell and tissue culture models by providing a high-throughput, functional system for testing cardio safety and efficacy to screen and identify compounds or pathways that may alter cardiac physiology and pathology. The high-content analysis of human engineered tissues is instrumental in ...
The heart is a unique organ in many respects since its activity is mandatory to sustain life. The heart’s circulatory system and coronary flow regulation are highly adapted to the vital role of the heart in sustaining life and to everyday physiological challenges. Understanding coronary physiology is key for treating patients with ischemic heart disease in general, and ...
On the other hand, whole transcriptome sequencing can not only characterize lncRNAs and circRNAs in samples, but also perform a global analysis of small RNAs, enrich and identify their target genes, and help construct and map ncRNA and mRNA (competitive endogenous RNA, eRNA) regulatory networks to enable the study of relevant physiological and pathological ...
Professor Cravatt, a professor in the Department of Chemistry at the Scripps Research Institute, focuses on understanding protein function in human physiological and pathological processes and using the resulting knowledge to discover innovative therapeutic targets, as well as new drugs for the treatment of diseases. ...
DBiT-seq can be adopted by researchers with no experience in microfluidics and may find applications in a range of fields including developmental biology, cancer biology, neuroscience, and clinical pathology. Introduction In multicellular systems, cells do not function in isolation but are strongly influenced by spatial location and surroundings ( Knipple et al., 1985 ; ...