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Pre Clinical Effectiveness Case Study Articles & Analysis: Older
70 articles found
In recent years, adeno-associated virus (AAV) particles have emerged as a pivotal tool in the realm of gene therapy, offering researchers and clinicians innovative approaches to treat a variety of genetic disorders. Premade AAV particles represent a significant advancement in this field, streamlining the process of gene delivery and significantly enhancing the efficiency and efficacy of ...
Alfa Cytology has introduced its advanced drug development services for brain tumors. Alfa Cytology, celebrated for its cutting-edge biotech solutions and extensive tumor research expertise, has recently introduced brain tumor drug development services, designed to empower researchers in understanding the intricacies and unique challenges associated with brain tumors. Brain tumors represent a ...
The scientific realm of biomedicine has witnessed extraordinary evolution in recent years, particularly in the spheres of cell and gene therapies. These therapies have radically revamped disease treatment modalities, transcending traditional approaches to become some of the most groundbreaking advancements in modern healthcare. This article aims to engage in an incisive analysis of cell and gene ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro cell cultures and the ...
Alfa Cytology has announced pancreatic cancer vaccine development services to improve the efficacy and safety of related vaccines. Alfa Cytology, a biotech company composed of scientists, bioinformatics, and oncologists, has recently announced its pancreatic cancer vaccine development services to provide further strategies for cancer therapy research. Compared to other solid tumors, ...
Alfa Cytology has announced its small molecule drug development to advance preclinical cancer research. Alfa Cytology, a comprehensive biotech company specializing in cancer research, has recently announced the cancer small molecule drug development services. The services tend to accelerate the discovery and optimization of molecule drugs with a strict quality control system. Small molecule drugs ...
Host cell proteins (HCPs) are protein impurities produced by genetically engineered strains or cell lines. Some of these proteins are necessary for the survival, reproduction and other normal physiological activities of engineered strains or cell lines. HCPs are purified together with the target product during the production process and cannot be removed. Risks of HCPs In general, HCP ...
By targeting specific pathways critical to the growth and survival of the excretory system, the scientists aim to develop more effective and less toxic treatments for brain excretory mechanisms. At the same time, pre-clinical studies are also significant to assess the efficacy and safety of small molecule drugs in brain cancer ...
The development of monoclonal antibodies (mAbs) has completely transformed the field of medicine, providing targeted antidotes against a wide range of diseases, including cancer, autoimmune and infectious diseases. These therapeutic antibodies aim to specifically target antigens on the surface of cells and bind to them, leading to acidic reactions that result in the destruction of target cells. ...
MtoZ Biolabs, leveraging high-precision mass spectrometry technology in conjunction with a chemical proteomics platform, provides you with high quality Collagen Analysis services and other Medical Device services. As a leading biotechnology company, MtoZ Biolabs is committed to providing comprehensive, one-stop CRO testing services to scientific research institutions and pharmaceutical companies ...
Binding of adjuvants to antigens can increase the surface area of the antigen, and the biological effects include (1) deposit effect of antigen; (2) upregulation of cytokine and chemokine expression, and recruitment of immune cells at the injection site; (3) activation of inflammasome; and (4) carrier effects. ...
Antibody drug conjugates (ADCs) are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a total of 15 ADC drugs have been approved worldwide, of which the FDA has approved 13 ADCs for various cancers, including Adcetris®, Kadcyla®, Besponsa®, Mylotarg®, Lumoxiti®, Polivy®, Padcev®, Enhertu ®, Trodelvy® and Blenrep®. As ...
With the rapid development of antibody-drug conjugate (ADC), more and more companies have entered the field of ADC research and development, and various types of ADC technologies and branches have emerged. Bispecific antibody conjugates (BsAb ADCs) are one of the emerging new technologies. The high specificity of bispecific antibodies enables more precise targeting of tumor cells. On the other ...
The scientific realm of biomedicine has witnessed extraordinary evolution in recent years, particularly in the spheres of cell and gene therapies. These therapies have radically revamped disease treatment modalities, transcending traditional approaches to become some of the most groundbreaking advancements in modern healthcare. This article aims to engage in an incisive analysis of cell and gene ...
Antibody drug conjugate (ADC) research involves more and more targets, such as HER-2, Trop-2, Claudin-18.2, B7-H3 and B7-H4, etc. Trop-2 is a transmembrane glycoprotein. Its high expression is associated with the occurrence of many tumors and poor prognosis. It is a very popular ADC research target, second only to HER2. Currently, only Gilead's Trop-2 ADC drug Trodelvy has been approved for ...
What is cystic fibrosis? Cystic fibrosis (CF) is a rare genetic disorder that affects the lungs, digestive system, and other organs. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a protein that regulates chloride ions transport across cell membranes. These mutations cause the CFTR protein to be either absent or not function ...
What Are the Advantages of Single-Cell RNA Sequencing? One of the significant advantages of scRNA-seq in drug discovery is its impact on target identification. By allowing researchers to dissect complex tissues and diseases at the cellular level, scRNA-seq enables the identification of distinct cell subtypes and their gene expression profiles. This information can lead to a better understanding ...
1. Understanding animal behavior: Animal cognitive behavioral tests help researchers gain insight into how animals think, learn, and solve problems. By conducting cognitive behavioral tests, scientists can better understand the cognitive abilities of different animal species and how they compare to humans. 2. Comparative studies: Comparative cognition research is important for understanding the ...
In the world of pharmaceuticals, developing safe and effective drugs is a complex and time-consuming process. Before a new drug candidate can progress to clinical trials and ultimately reach the market, it needs to undergo rigorous testing in various model systems to assess its efficacy and safety. One critical component of this evaluation is the use of preclinical animal models. Preclinical ...
Nuritas has discovered two ingredients called PeptiYouth and PeptiStrong that can be integrated into everyday products, including serums and supplements, to fight the effects of aging on skin and muscles. The company names stem cell aging as a growing focus for start-ups. It also says one of consumers’ most significant concerns is combating the adverse effects of aging. Nuritas uses its ...