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Pre Clinical Effectiveness Case Study Articles & Analysis
83 articles found
In preclinical respiratory studies, traditional methods like plethysmography often require animal restraint and extensive acclimation, limiting their ability to capture dynamic respiratory changes. To overcome these challenges, IPS Therapeutique Inc. validated a novel telemetry-based technique for continuous monitoring of intrapleural pressure and respiratory patterns in conscious, freely ...
ELANE, or neutrophil elastase (NE), is a serine protease stored in the azurophilic granules of neutrophils and is encoded by the ELANE gene on chromosome 19. It plays a pivotal role in the host defense system by degrading bacterial proteins, remodeling extracellular matrices, and shaping inflammatory responses. However, the same proteolytic activity that protects against pathogens can, when ...
Matrix Gla Protein (MGP) is a small, vitamin K-dependent extracellular matrix protein that plays a critical role in the regulation of vascular calcification and bone development. As a natural inhibitor of pathological mineralization, MGP has attracted significant attention in cardiovascular and skeletal biology research. The development of recombinant MGP protein has enabled researchers to study ...
Tissue cross-reactivity studies play an essential role in the understanding of immune responses, particularly in the context of autoimmunity, transplant rejection, and vaccine development. These studies aim to identify whether antibodies or T cells generated against a particular antigen react with similar proteins found in different tissues, which can lead to unintended effects and complications. ...
Lipids, often simply thought of as fats, play a far more complex and vital role in our bodies than just energy storage. They are fundamental building blocks for cell membranes, crucial for nutrient absorption, and, significantly, the precursors to a powerful class of signaling molecules: steroid hormones. Understanding the deep connection between Lipid Metabolism and these hormones, along with ...
Alfa Cytology has revealed new FAP-targeted therapeutics development services that aim to develop precise and effective cancer treatments. Alfa Cytology has introduced its groundbreaking initiative which targets fibroblast activation protein(FAP) for cancer therapies. These solutions focusing on FAP to improve treatment accuracy and deliver customized projects that strive to obtain more ...
Alfa Cytology has officially released its antibody-drug conjugates(ADCs) development services which demonstrates the dedication to fighting cancer through advanced treatment methods. Alfa Cytology, which stands at the forefront of oncology service provision in New York United States, has announced its sophisticated antibody-drug conjugates(ADCs) development services for cancer. The pioneering ...
In recent years, the fight against cancer has seen significant advances, particularly with the emergence of targeted therapy. Among the most promising strategies in this domain is the development of radioactive drug conjugates(RDCs). These innovative therapeutic agents combine the targeting capabilities of antibodies with the cytotoxic effects of radioactive isotopes, providing a powerful ...
Preclinical drug discovery represents a critical phase in the development of new therapeutics. It is the process that bridges the gap between basic research and clinical testing, allowing for the evaluation of potential drug candidates in biological systems before they are tested in humans. Central to this phase is the use of appropriate disease models, which are essential for understanding the ...
The quest for effective therapeutics begins long before a drug reaches clinical trials. One of the cornerstones of this process is drug screening in animal models, which plays a pivotal role in evaluating the safety and efficacy of potential treatments. Animal models offer researchers valuable insights that cannot be obtained through in vitro studies alone, bridging the gap between laboratory ...
Alfa Cytology unveils advanced cancer immunotherapy development services. Alfa Cytology, a renowned services supplier in oncology, has recently introduced its groundbreaking cancer immunotherapy development services. This initiative signifies a major leap forward in the development of more effective cancer therapies, aiming to boost both precision and versatility within treatment paradigms. ...
Alfa Cytology has launched ovarian cancer therapy development services. Alfa Cytology, a prominent services provider in oncology, has launched its cutting-edge ovarian cancer therapy development services. This significant advancement represents a vital leap in the quest for more precise and effective treatments for ovarian cancer. With the complexities of ovarian cancer treatment becoming ...
The evaluation of cardiovascular toxicity is a significant challenge in drug development. Preclinical evaluation of cardiovascular safety involves a multifaceted approach, encompassing a plethora of in vitro and in vivo endpoints. These assessments continuously evolve, aiming to mitigate the incidence of cardiovascular toxicity that may emerge during clinical trials. To shed light on the ...
In recent years, adeno-associated virus (AAV) particles have emerged as a pivotal tool in the realm of gene therapy, offering researchers and clinicians innovative approaches to treat a variety of genetic disorders. Premade AAV particles represent a significant advancement in this field, streamlining the process of gene delivery and significantly enhancing the efficiency and efficacy of ...
Alfa Cytology has introduced its advanced drug development services for brain tumors. Alfa Cytology, celebrated for its cutting-edge biotech solutions and extensive tumor research expertise, has recently introduced brain tumor drug development services, designed to empower researchers in understanding the intricacies and unique challenges associated with brain tumors. Brain tumors represent a ...
The scientific realm of biomedicine has witnessed extraordinary evolution in recent years, particularly in the spheres of cell and gene therapies. These therapies have radically revamped disease treatment modalities, transcending traditional approaches to become some of the most groundbreaking advancements in modern healthcare. This article aims to engage in an incisive analysis of cell and gene ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro cell cultures and the ...
Alfa Cytology has announced pancreatic cancer vaccine development services to improve the efficacy and safety of related vaccines. Alfa Cytology, a biotech company composed of scientists, bioinformatics, and oncologists, has recently announced its pancreatic cancer vaccine development services to provide further strategies for cancer therapy research. Compared to other solid tumors, ...
Alfa Cytology has announced its small molecule drug development to advance preclinical cancer research. Alfa Cytology, a comprehensive biotech company specializing in cancer research, has recently announced the cancer small molecule drug development services. The services tend to accelerate the discovery and optimization of molecule drugs with a strict quality control system. Small molecule drugs ...
Host cell proteins (HCPs) are protein impurities produced by genetically engineered strains or cell lines. Some of these proteins are necessary for the survival, reproduction and other normal physiological activities of engineered strains or cell lines. HCPs are purified together with the target product during the production process and cannot be removed. Risks of HCPs In general, HCP ...