Preclinical In Vivo Model Articles & Analysis
37 articles found
Idiopathic pulmonary fibrosis (IPF) is a devasting lung disease characterized by progressive scarring of lung tissue. As fibrosis develops, patients experience worsening shortness of breath, reduced lung capacity and ultimately respiratory failure. Current therapies for IPF rely on oral administration of pirfenidone and nintedanib, two FDA-approved drugs that slow disease progression. While ...
The BCL2 gene, short for B-cell lymphoma 2, is a critical regulator of apoptosis, or programmed cell death. It belongs to a larger BCL2 gene family, which includes both pro-apoptotic and anti-apoptotic proteins that maintain a delicate balance between cell survival and cell death. Dysregulation of this gene family is implicated in a variety of diseases, most notably cancer. What is BCL2? The ...
For instance, CXCL10 has shown promise in preclinical models by enhancing T-cell infiltration into tumors. Additionally, chemokines play a role in vaccine development. ...
Pre-Clinical Analysis Services for RDCs Preclinical research is a crucial phase in the drug development process, particularly for Radiopharmaceuticals and Drug Conjugates(RDCs). ...
Alfa Cytology unveils advanced PD-1 inhibitor development service for cancer research. Alfa Cytology, a prominent service provider in the oncology landscape, has recently launched its innovative PD-1 inhibitor development services. This initiative marks a significant advancement in the quest for more effective cancer therapies, focusing on enhancing precision and adaptability in treatment ...
The quest for effective therapeutics begins long before a drug reaches clinical trials. One of the cornerstones of this process is drug screening in animal models, which plays a pivotal role in evaluating the safety and efficacy of potential treatments. Animal models offer researchers valuable insights that cannot be obtained through in vitro studies alone, bridging the gap between laboratory ...
Alfa Cytology has launched ovarian cancer therapy development services. Alfa Cytology, a prominent services provider in oncology, has launched its cutting-edge ovarian cancer therapy development services. This significant advancement represents a vital leap in the quest for more precise and effective treatments for ovarian cancer. With the complexities of ovarian cancer treatment becoming ...
Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant public health concern, associated with obesity, insulin resistance, and a spectrum of metabolic disorders. Understanding this condition is crucial for effective intervention and treatment. Preclinical models are indispensable for advancing our knowledge of NAFLD, as they provide the necessary platforms to study its ...
Furthermore, while liposomes have shown promise in preclinical models, translation to the clinical setting has been met with variable success. Factors such as complex in vivo dynamics and interpatient variability can affect liposome pharmacokinetics and biodistribution, underscoring the need for more predictive preclinical ...
Alfa Cytology has announced pancreatic cancer vaccine development services to improve the efficacy and safety of related vaccines. Alfa Cytology, a biotech company composed of scientists, bioinformatics, and oncologists, has recently announced its pancreatic cancer vaccine development services to provide further strategies for cancer therapy research. Compared to other solid tumors, ...
Sudden Unexpected Death in Epilepsy (SUDEP) remains a critical concern in epilepsy management, with the underlying mechanisms still not fully understood. Recent research from Iyer, S., et al (2024) has highlighted the role of respiratory dysfunction in SUDEP, particularly involving the orexinergic system in the brain. This blog delves into a fascinating study that investigates how altered ...
Adjuvants can help antigens induce long-term effective specific immune responses in vivo, leading to higher vaccine efficacy and prolonged protection from immune responses. ...
Rare diseases, also known as orphan diseases, are a diverse group of disorders that affect a small percentage of the population. Due to their low prevalence and limited understanding, treating and finding cures for these conditions present significant challenges. However, preclinical animal models have emerged as invaluable resources for advancing research and unraveling the mysteries surrounding ...
With the rapid development of antibody-drug conjugate (ADC), more and more companies have entered the field of ADC research and development, and various types of ADC technologies and branches have emerged. Bispecific antibody conjugates (BsAb ADCs) are one of the emerging new technologies. The high specificity of bispecific antibodies enables more precise targeting of tumor cells. On the other ...
To better understand the role of CD73 in tumorigenesis, multiple CD73-deficient tumor models have been studied, shedding light on its importance in both tumor cells and host cells[17]. ...
Antibody drug conjugate (ADC) research involves more and more targets, such as HER-2, Trop-2, Claudin-18.2, B7-H3 and B7-H4, etc. Trop-2 is a transmembrane glycoprotein. Its high expression is associated with the occurrence of many tumors and poor prognosis. It is a very popular ADC research target, second only to HER2. Currently, only Gilead's Trop-2 ADC drug Trodelvy has been approved for ...
What Are the Advantages of Single-Cell RNA Sequencing? One of the significant advantages of scRNA-seq in drug discovery is its impact on target identification. By allowing researchers to dissect complex tissues and diseases at the cellular level, scRNA-seq enables the identification of distinct cell subtypes and their gene expression profiles. This information can lead to a better understanding ...
In the world of pharmaceuticals, developing safe and effective drugs is a complex and time-consuming process. Before a new drug candidate can progress to clinical trials and ultimately reach the market, it needs to undergo rigorous testing in various model systems to assess its efficacy and safety. One critical component of this evaluation is the use of preclinical animal models. Preclinical ...
Advantages of Single-Cell RNA Sequencing in Drug Discovery Single-Cell RNA Sequencing (scRNA-seq) offers several advantages in drug discovery, primarily through target identification. By analyzing complex tissues and diseases at the cellular level, scRNA-seq allows researchers to identify distinct cell subtypes and their gene expression profiles. This knowledge enhances our understanding of ...
The clinical presentation of COVID-19-related illness ranges from asymptomatic to mild respiratory symptoms resembling influenza infection to acute symptoms including pneumonia requiring hospitalization and admission to the intensive care unit. COVID-19 starts in the upper airways and lungs, but in severe cases can also affect the heart, blood vessels, brain, liver, kidneys, and intestines. ...