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Preclinical Trial Articles & Analysis
83 articles found
In preclinical respiratory studies, traditional methods like plethysmography often require animal restraint and extensive acclimation, limiting their ability to capture dynamic respiratory changes. To overcome these challenges, IPS Therapeutique Inc. validated a novel telemetry-based technique for continuous monitoring of intrapleural pressure and respiratory patterns in conscious, freely ...
ELANE, or neutrophil elastase (NE), is a serine protease stored in the azurophilic granules of neutrophils and is encoded by the ELANE gene on chromosome 19. It plays a pivotal role in the host defense system by degrading bacterial proteins, remodeling extracellular matrices, and shaping inflammatory responses. However, the same proteolytic activity that protects against pathogens can, when ...
Matrix Gla Protein (MGP) is a small, vitamin K-dependent extracellular matrix protein that plays a critical role in the regulation of vascular calcification and bone development. As a natural inhibitor of pathological mineralization, MGP has attracted significant attention in cardiovascular and skeletal biology research. The development of recombinant MGP protein has enabled researchers to study ...
Tissue cross-reactivity studies play an essential role in the understanding of immune responses, particularly in the context of autoimmunity, transplant rejection, and vaccine development. These studies aim to identify whether antibodies or T cells generated against a particular antigen react with similar proteins found in different tissues, which can lead to unintended effects and complications. ...
Lipids, often simply thought of as fats, play a far more complex and vital role in our bodies than just energy storage. They are fundamental building blocks for cell membranes, crucial for nutrient absorption, and, significantly, the precursors to a powerful class of signaling molecules: steroid hormones. Understanding the deep connection between Lipid Metabolism and these hormones, along with ...
According to active collaboration with scientists and clinical experts, the company promotes innovation and speeds up laboratory discoveries to help preclinical practice. Through strategic partnerships, Alfa Cytology focuses on developing FAP-targeted therapies that provide advanced tools for researchers to revolutionize cancer treatment protocols. ...
The company seeks to advance innovation and improve the preclinical implementation of laboratory breakthroughs through its collaboration with scientists and oncologists. ...
In Vitro and In Vivo Studies: Prior to human trials, extensive laboratory studies are conducted to evaluate the efficacy, stability, and safety of the conjugate. ...
Preclinical drug discovery represents a critical phase in the development of new therapeutics. ...
The quest for effective therapeutics begins long before a drug reaches clinical trials. One of the cornerstones of this process is drug screening in animal models, which plays a pivotal role in evaluating the safety and efficacy of potential treatments. ...
Moreover, the services on ovarian cancer model development allow researchers to utilize state-of-the-art preclinical models that closely mimic human ovarian cancer biology. These models enable the in-depth study of tumor behavior and therapeutic response, facilitating the discovery of novel treatment avenues tailored to individual patient profiles. ...
Services provided include comprehensive support in drug development, preclinical trial design, and strategic planning for laboratory discoveries into preclinical ...
The evaluation of cardiovascular toxicity is a significant challenge in drug development. Preclinical evaluation of cardiovascular safety involves a multifaceted approach, encompassing a plethora of in vitro and in vivo endpoints. These assessments continuously evolve, aiming to mitigate the incidence of cardiovascular toxicity that may emerge during clinical ...
Furthermore, it has led to accelerated timelines for preclinical and clinical trials, ultimately benefiting patients awaiting lifesaving therapies. ...
This inclusive service design guarantees the efficacy and safety of drugs for further applications, including preclinical trials and regulatory submission. Complementing their drug development efforts, Alfa Cytology also spearheads vaccine development services for brain tumors, focusing on harnessing the body’s immune response to combat tumors. ...
Hence, an extensive lattice of regulations envelops these modalities, mandating rigorous preclinical studies and clinical trials before their eventual public deployment. ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro cell cultures and the ...
Alfa Cytology has announced pancreatic cancer vaccine development services to improve the efficacy and safety of related vaccines. Alfa Cytology, a biotech company composed of scientists, bioinformatics, and oncologists, has recently announced its pancreatic cancer vaccine development services to provide further strategies for cancer therapy research. Compared to other solid tumors, ...
Alfa Cytology has announced its small molecule drug development to advance preclinical cancer research. Alfa Cytology, a comprehensive biotech company specializing in cancer research, has recently announced the cancer small molecule drug development services. ...
Host cell proteins (HCPs) are protein impurities produced by genetically engineered strains or cell lines. Some of these proteins are necessary for the survival, reproduction and other normal physiological activities of engineered strains or cell lines. HCPs are purified together with the target product during the production process and cannot be removed. Risks of HCPs In general, HCP ...