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Protein Therapeutic Articles & Analysis
15 articles found
Knockin cell line generation represents a pivotal advancement in genetic engineering, providing vital tools for biological research and therapeutic development. This process involves the integration of specific DNA sequences into precise loci within the genome, allowing scientists to explore gene function, model diseases, and develop new treatments. ...
In the realm of biotechnology and pharmaceuticals, stable cell lines serve as a foundation for producing high-yield protein therapeutics, monoclonal antibodies, and vaccines. They are routinely employed to study gene function, signal transduction pathways, and drug screening processes. ...
Recombinant protein drugs are protein-based therapeutic drugs which are produced by using DNA recombination technology or other biotechnological methods. These drugs include cytokines, peptide hormones, recombinant enzymes, monoclonal antibodies, and fusion proteins. Compared to traditional low-molecular-weight synthetic drugs, ...
HCP (Host Cell Proteins) residual detection is a key quality control step in the field of biopharmaceuticals, aiming at ensuring that the proteins of the host cells used for producing therapeutic proteins in any cell-based production system are maintained at acceptable low levels in the final drug product.ImportanceHCPs are ...
Recombinant protein drugs are therapeutic protein drugs produced using DNA recombination technology or other biotechnologies. Compared to traditional low molecular synthetic drugs, they have the advantages of strong specificity, low toxicity, and significant therapeutic effects. However, as biological macromolecular drugs, ...
These methods can increase the expression of coding and non-coding genes specifically and controllably, reducing development and manufacturing costs and thus expanding the range of treatable diseases. Based on the demonstrated therapeutic potential and significant unmet medical needs, NBT is poised for rapid advancement in the future.Biological Upregulation of ...
Key Applications of Biopharma PEG's Azide PEG Series: ADCs and PROTACs: The Azide PEG series plays a pivotal role in the development of ADCs, connecting antibodies with cytotoxic drugs, and in PROTACs, facilitating the degradation of specific proteins for innovative therapeutic approaches. Drug Delivery: Biopharma PEG's Azide PEGs enhance drug solubility, ...
The plasmid carries the gene coding for the protein of interest, and the cell's machinery copies this gene and uses it as a blueprint to manufacture the protein. ...
The interaction between HCPs and therapeutic proteins is first removed by anionic surfactants, so that HCPs can be enriched using a molecular weight cut-off (MWCO) ultrafiltration step, and then identified by a "shotgun" quantitative proteomics technique and analysis of HCP in therapeutic protein drugs. ...
Scientists continuously face pressure to purify biologics like protein therapeutics with maximum yield while minimizing cost and developing processes as quickly as possible. ...
Since the 1970s, PEG has been used to modify therapeutic proteins and peptides in order to increase their solubility, reduce their toxicity, and prolong their cyclic half-lives. ...
Oxford Global kicked off another exciting discussion group all about RNA therapeutics and emerging technologies for their delivery. Those attending were experts from the leading authorities in the field. ...
AlphaFold AI System can change the world While 2020 was a difficult time across many metrics, it was an exciting year for protein science! AlphaFold gained international acclaim for advancing protein structure prediction after blowing the competition out of the water at CASP in both the 2018 and 2020 competitions (1). The AlphaFold system uses AI to decipher an unknown protein structure by ...
Another VIC portfolio company with an important technology relevant to viruses impacting the respiratory system is Nob Hill Therapeutics (NHT). Cases of COVID-19 frequently have led to deadly secondary infections like pneumonia. ...
But the most fundamental issue still seems to be that many proteins are not recognized by animal immune systems, which generate the polyclonal sera used as reagents in these assays. ...