Renal Toxicity Articles & Analysis
3 articles found
This results in reduced aggregation, lower immunogenicity, better pharmacokinetics, longer circulation time, and less toxicity. Products include: mPEG36-NH2 (CAS NO.: 32130-27-1) OH-PEG6-COOH (CAS NO.: 1347750-85-9) CBZ-NH-PEG3-COOH (CAS NO.: 1310327-18-4) OH-PEG9-OH (CAS NO.: 3386-18-3) PEGs as PROTAC Linkers PEG linkers are the most common in PROTAC molecules. ...
Li et al constructed a novel siRNA delivery system sTOLP(loaded with siRNAOA-R8 / TF-modified LNP) for cell penetrating peptioyl-octadecarginine (OA-R8) transferrin (Tf)-modified multifunctional lipid nanoparticles (LNP). siRNA encapsulated in sTOLP showed strong tumor inhibition (61.7%) and was preferentially absorbed by hepatocytes and tumor cells in HepG2-containing mice without inducing ...
Experiments revealed that the siRNA encapsulated in the sTOLP delivery system showed strong tumor inhibition (61.7%) and can be preferentially absorbed by hepatocytes and tumor cells in HepG2-containing mice without inducing immunogenicity or hepatic or renal toxicity, which brings promise to tumor-specific therapies. 2. ...