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Research Analyzer Articles & Analysis
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Applications of Custom Knockout Cell Lines Functional Genomics: By knocking out genes, researchers can systematically analyze their roles in cellular pathways and processes. ...
This multiplexing ability is critically important for researchers analyzing complex biological pathways, immune responses, and disease biomarkers. ...
The significance of degradome sequencing lies in its ability to provide a more accurate and reliable identification of miRNA target genes compared to traditional bioinformatics predictions. By directly analyzing mRNA degradation fragments, researchers can validate miRNA interactions with target genes more effectively, thus simplifying subsequent experimental ...
Applications in Research In the realm of scientific research, miRNA mimics serve as invaluable tools for investigating the role of specific miRNAs in various biological processes. ...
Through techniques such as next-generation sequencing (NGS), researchers can analyze huge volumes of genetic data, enabling the detection of even slight genetic variations among clones. ...
Ubiquitination detection of proteins is a biochemical technique used to identify and analyze ubiquitination modifications on proteins. Ubiquitination is a post-translational modification process that involves the covalent linkage of the small protein ubiquitin to lysine residues of a target protein, a modification that plays a crucial role in the regulation of protein ...
Through techniques such as next-generation sequencing (NGS), researchers can analyze huge volumes of genetic data, enabling the detection of even slight genetic variations among clones. ...
Advantages of Single-Cell RNA Sequencing in Drug Discovery Single-Cell RNA Sequencing (scRNA-seq) offers several advantages in drug discovery, primarily through target identification. By analyzing complex tissues and diseases at the cellular level, scRNA-seq allows researchers to identify distinct cell subtypes and their gene expression profiles. ...
Structural biology is an important field in drug discovery as it helps researchers understand the three-dimensional structure of proteins and how they interact with other molecules. ...
The research goals of Carole Ober’s laboratory at the University of Chicago are to identify genetic variants that influence gene expression and epigenetic patterns in tissues relevant to complex phenotypes, especially related to asthma and fertility. The lab uses both freshly isolated cells, as well as tissue and cell culture models of gene-environment interactions to explore ...
AdvaitaBio’s IPathwayGuide plays significant role in the research of a Stanford investigator. Stanford University is one of the world’s leading research and teaching institutions. With a 1.69 billion dollar annual sponsored research budget, Stanford has been delivering breakthrough discoveries in numerous domains. For over 6 years, Dr. Linda Yip has been conducting research at ...
Among these DUBs, some of the main probe-modified cysteines are not located at the catalytic site and could be preferentially bound, and the researchers speculate that such DUBs are unlikely to lose catalytic activity after binding to their recruited ligands. Among the seven suitable DUBs found by the investigators to meet this criterion, OTUB1 was finally selected for further ...
Researchers at The University of Texas MD Anderson Cancer Center have identified a new strategy to reduce immune-related adverse events by targeting immunotherapy with the cytokine interleukin-6 (IL-6). ...
The Covid-19 pandemic highlighted the disparity between those who succumbed to severe illness while others remained relatively unaffected, underscoring the urgent need to shift the healthcare industry’s focus from a one-size-fits-all approach to more personalised healthcare. Personalised medicine promises to transform healthcare with treatments tailored to a patient’s unique genetic ...
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This change has been driven by the realization that researchers need to increase the depth and variety of RNA/DNA sequencing to capture a more comprehensive view. RNA-Seq is capable of annotating structural variants, allele-specific expression, and disease-associated SNPs by analyzing alternative splicing events. Coupled with bioinformatics pipelines, many ...
Recently, an article titled " MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade" was published in Nature Communications. By analyzing public genome databases, the researchers found that a large number of triple-negative breast cancer patients express high levels of MAPK4, and in animal models, elimination of ...
This study finds or is expected to help develop novel therapies for the treatment of rheumatoid arthritis. Researcher Michael Skinner said that if these patients can be found ten years in advance before the disease occurs, it may open up the entire field of research in preventive medicine that we previously could not obtain. ...
Environmental Protection Agency to: Develop, publish and update guidelines on an approach to investigate suspected or potential disease clusters, environmental pollutants, or toxic substances associated with such clusters, or potential causes of such clusters; Establish and operate Regional Disease Cluster Information and Response Centers and Regional Disease Cluster Information and Response ...
This research analyses the US Food and Drug Administration's (FDA's) risk methodology used for inspecting pharmaceutical manufacturing sites. It reviews the procedures, regulations, and violations specified in FDA warning letters (WLs). In particular it focuses on the time period between 2004-2009, as the FDA transitioned and formalised this new approach to site inspections. One of the principal ...
How CREMe is Helping Fight Childhood Obesity The Current State Of Affairs Childhood obesity has widely spread in industrialized countries. In the USA, over 15% of children are currently considered obese and the number is likely to grow in the future. In Ireland alone, about 300,000 children are overweight or obese. Obesity indirectly leads to about 2,000 deaths a year and also to ...