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Septic Super Shock Articles & Analysis
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The FDA's Center for Drug Evaluation and Research (CDER) regulatory approval of a total of 26 NME (New Molecular Entity) drugs in the first half of 2023. It is worth noting that the 26 drugs approved include 4 peptide drugs, accounting for 15% of the total. In the past 2022, the FDA has approved only three peptide drugs: Tirzepatide, Lutetium 177Lu Vipivotide Tetraxetan and Terlipressin, of which ...
Sepsis is a severe bodily reaction to infection, which can cause fever, breathlessness, disorientation, tissue damage, and organ failure, among other symptoms. While bacterial infections are the primary culprits, any other infection such as from pneumonia or influenza may lead to sepsis if not appropriately treated. Under normal circumstances the immune system of the body fights against any ...
The term sepsis describes the body's extreme response to infection. When a person suffers from sepsis, his or her immune system has been triggered in response to an infection, which causes inflammation and damages tissues in the body. Symptoms of Sepsis The symptoms of sepsis may include: Fever (102 degrees Fahrenheit or higher) Chills Rapid breathing (above 20 breaths per minute) or ...
In honor of World Cancer Day, we sat down with two Adapters to understand how their personal experiences with cancer intersect with their work at Adaptive. Kathy Thompson (Key Account Manager, clonoSEQ sales) is a stage 1 colorectal cancer survivor. Shannon Fatigante (Talent Acquisition Senior Program Manager) has a father currently fighting chronic lymphocytic leukemia (CLL). Shannon: ...
Sepsis accounts for over 20% of deaths worldwide (WHO) and 85% of cases occur in low-resource settings.But this isn’t a problem mostly owned by third-world countries with inadequate equipment and detection technology. In the U.S., less than 50% of patients are correctly treated for sepsis, mostly due to clinicians missing the timeline for treatment. The problem is so widespread that ...
The Problem: When Kevin Kronmiller was 22, he found out he had 5 years to live if he didn't receive a liver transplant. Beating the odds, Kevin made it to 50 before needing a liver transplant. After his surgery, Kevin went into Septic Shock. He found out later from his physicians that he had a 30% chance of survival and even if he did survive, doctors were very concerned about long-term ...
Sepsis reportedly affects up to 30 million people each year. Lactate levels play a key role in diagnosing the condition and limiting its impact, as well as researching it's progression and developing possible treatments. Here's how. Sepsis is a medical condition and emergency, the definition of which has proven difficult and is based on fairly recent developments and research. It is the result ...
Annotations Serum Gal-3 concentration increased in patients with septic shock and mice undergoing sepsis induced by a procedure called cecal ligation and puncture (CLP). Mice genetically deficient in Gal-3 (Gal-3 KO) were more resistant to sepsis caused by CLP than wild-type mice (WT). Gal-3 KO mice show an increased number of neutrophils in the initial stage of infection and reduced ...
The purpose of this case study is to highlight ways in which medical algorithms can be integrated into the clinical decision making process. This case study is the first of a series focused on sepsis, a common but complex clinical problem. Use of algorithms can help healthcare providers diagnose sepsis early. Throughout our discussion, appropriate algorithms are suggested to help clinicians ...