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Spectroscopy Articles & Analysis: Older
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In these situations, even minor limitations in monitoring capability can lead to hypoxemia, a leading cause of morbidity and mortality during surgical procedures, making accurate and responsive oxygen concentration monitoring a critical safeguard for patient outcomes.4Recognizing the vital importance of precise oxygen monitoring, Cubic, an international manufacturer of advanced gas sensors and ...
Pharmaceutical manufacturers face growing challenges in ensuring product quality, maintaining regulatory compliance, and safeguarding against counterfeit drugs. Near-infrared (NIR) spectroscopy is an important tool in this arena, offering rapid, non-destructive analysis for raw material identification, impurity detection, and counterfeit screening. By integrating NIR ...
This technology enables the detailed identification and quantification of lipids and metabolites from small samples like exosomes, which are typically limited in number. NMR spectroscopy is another useful technique in metabolomics, providing structural information on metabolites. ...
Mass Spectrometry (MS)(1) Mass spectrometry is a highly sensitive and accurate analysis method that can be used to identify and quantify the mass and composition of chemicals.(2) When combined with liquid chromatography (such as LC-MS) or gas chromatography (such as GC-MS), this technique can provide detailed information about trace components in the medium.3. Ultraviolet-Visible ...
The content of collagen can be accurately determined by comparing the chromatographic peaks of unknown samples with those of standard products with known concentrations.SpectroscopyUltraviolet-visible (UV-Vis) absorption spectroscopy can be used to measure the concentration of collagen, as proteins absorb ultraviolet light at specific wavelengths (such as 280nm). ...
Protein Secondary Structure AnalysisCD spectroscopy can be used to determine the different types of secondary structure present in a protein, and monitor changes in these structures under various environmental conditions (such as different pH, temperature, or presence/absence of cofactors). ...
Ensuring the purity, concentration and conformational stability of the drug is crucial, which not only relates to the efficacy of the drug, but also affects its safety.Ultraviolet spectroscopy technique is based on the absorption characteristics of antibody proteins to specific wavelengths of ultraviolet light, and can provide rapid and non-destructive detection of drug ...
Spectroscopic MethodsInfrared spectroscopy and Raman spectroscopy can also be used to analyze the glycation structure and changes of collagen.These methods can be used separately or in combination to obtain a comprehensive understanding of the structure and function of glycated collagen.The detection of glycated collagen is also one of the methods used to assess ...
Through specific immune reactions, the target protein and the proteins it binds to are "captured". By using protein spectroscopy and other means for identification, the interactions between proteins can be understood. ...
Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy. Proceedings of the National Academy of Sciences. 2009 Dec 29;106(52). ...
The detection methods for glycosylated impurities are diverse, including chromatography, spectroscopy, electrophoresis, etc. Among them, High-Performance Liquid Chromatography (HPLC) is the most commonly used detection method, which can effectively separate and quantitatively analyze glycosylated impurities, with simple operation and good repeatability. ...
Nuclear Magnetic Resonance (NMR) Spectroscopy NMR spectroscopy plays a critical role in structural elucidation of ADCs. ...
Ultraviolet-Visible (UV-Vis) Spectroscopy(1) PrincipleUV-Vis spectroscopy utilizes the absorption characteristics of proteins in the ultraviolet region (especially around 280 nm) to monitor structural changes.(2) OperationMeasure the ultraviolet absorption spectrum of a collagen solution at different temperatures. ...
Studying the distribution of DAR values helps to understand the overall fate of ADCs and provides a theoretical basis for ADC biotransformation in vivo. UV/VIS spectroscopy is widely used to determine antibody concentration and DAR value, but this method is a buffer system and cannot be applied to complex biological systems such as plasma/serum. ...
Hydrogen is the most common target nucleus (1H-NMR), while other atoms such as carbon (13C-NMR) and phosphorus (31P-NMR) can also be used to obtain information on specific metabolite types by NMR techniques. Currently, 1H-NMR spectroscopy, 2H-NMR spectroscopy, and high-resolution magic angle rotation (HRMAS-NMR) spectroscopy are common. ...
Based on the principle of TDLAS (Tunable Diode Laser Absorption Spectroscopy), Gasboard-2510 oxygen sensor could realize high accuracy and excellent repeatability, with a measurement range of 0%~100% level and a resolution up to 0.01. ...
Analytical techniques such as chromatography, spectroscopy, and mass spectrometry are commonly used in pharmaceutical analysis to identify and quantify active pharmaceutical ingredients and impurities. ...
The medical industry is a new frontier for Raman spectroscopy. In the past few years, Raman has been used in dental and cancer studies, and is now building on this success by extension into Point-of-Care (POC) applications. This article gives an overview of some very new and exciting research into the use of Raman spectroscopy for the detection of cancerous ...
ByB&W Tek
Structural information can be obtained using X-ray diffraction (for AH adjuvants only), spectroscopy (FTIR, NMR, Raman) and transmission electron microscopy. Granularity Aluminum adjuvants typically consist of primary nanoparticles that form irregularly shaped aggregates ranging in size from 1 to 20 μm. ...
Nitrogen-15 is often used in Nitrogen-15 NMR spectroscopy. Unlike the more abundant14 N,15 N has one-half the fractional nuclear spin, which provides the advantage of a narrower line width for NMR. ...