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Stress Response Articles & Analysis
42 articles found
In plant biotechnology, tissue culture, and stress physiology studies, knowing whether cells are alive or dead is essential for interpreting experimental results. ...
It plays a pivotal role in the host defense system by degrading bacterial proteins, remodeling extracellular matrices, and shaping inflammatory responses. However, the same proteolytic activity that protects against pathogens can, when unregulated, contribute to tissue injury, autoimmune inflammation, and chronic disease progression. ...
Podocytes are unique epithelial cells located in the glomerulus, a key component of the nephron responsible for filtering blood. They possess a complex morphology, characterized by numerous projections that interdigitate with neighboring podocytes to form a selective barrier. ...
For instance, L. acidophilus ATCC 4356 possesses 17 phosphotransferase systems versus 20 in NCFM, influencing carbon source utilization in experimental systems. Stress response mechanisms: Differential expression of heat shock proteins, particularly GroEL and DnaK chaperones, correlates with viability post-lyophilization—a critical consideration when ...
This method is particularly valuable for identifying the target genes regulated by microRNAs (miRNAs), which are small, endogenous non-coding RNAs approximately 22 nucleotides in length. miRNAs play crucial roles in various biological processes, including cell proliferation, apoptosis, differentiation, metabolism, and responses to environmental stresses such as ...
For instance, some differentially expressed proteins may be associated with disease progression, drug responses, or cellular stress responses.ApplicationsResearch on differentially expressed proteins has applications in many fields, including cancer, neurodegenerative diseases, metabolic diseases, etc. ...
Ubiquitination is a post-translational modification process that involves various biological processes, including signal transduction, cell cycle regulation, cell stress responses, and cell apoptosis. It plays a crucial role in maintaining protein homeostasis, regulating various biological reactions in cells, and ensuring the normal physiological functions of ...
Energy production is a cellular response to the demand for energy. Therefore, cellular ATP production varies depending on the state of the cell and the surrounding environment. ...
By cleaving RNA molecules, RNases are integral to numerous biological processes, ranging from RNA maturation to the innate immune response against RNA viruses. In this exploration, we delve into the multifaceted nature of ribonucleases, examining their structure, function, and potential in biotechnology. ...
Biological Effects Histone SUMOylation plays a role in regulating stress responses, cell cycle and cell differentiation. Additionally, it is closely associated with the process of DNA damage repair. 4. ...
Cell Cycle Control During specific stages of the cell cycle, such as during mitosis, the pattern of histone phosphorylation changes, affecting chromatin compaction and separation. 3. DNA Damage Response In the event of DNA damage, histone phosphorylation aids in the activation of repair mechanisms by recruiting repair proteins to the damage site. 4. Signal Transduction Histone ...
Phosphorylation Usually occurs on serine or threonine residues, it is a dynamic and reversible modification that affects gene expression, cell cycle, and DNA damage response. 4. Ubiquitination Addition of ubiquitin protein is associated with protein degradation, but ubiquitination on histones can also influence chromatin structure and function. 5. ...
It is well known that miRNAs are involved in many essential cellular processes, such as cell proliferation, differentiation, apoptosis, stress response and tumorigenesis etc. MiRNAs function in RNA silencing and post-transcriptional regulation of gene expression. ...
Drug Discovery and Development: DGE analysis facilitates the identification of genes responsive to specific drug treatments. By unraveling the molecular mechanisms underpinning drug response, we can optimize treatment strategies, expedite drug discovery, and develop personalized therapies tailored to individual patients. ...
By unraveling the molecular mechanisms underlying drug response, we can optimize treatment strategies, expedite drug discovery, and develop personalized therapies tailored to individual patients. ...
Since the 19th century, the practice of tissue processing has remained largely unchanged, resulting in solidified, paraffin-embedded tissue blocks for sectioning. As staining procedures have advanced and immunohistochemistry is becoming more widely used, high-quality tissue sections are paramount for accurate interpretation of disease ...
The analysis of intestinal barrier function changes in post-trauma animal models showed that small intestinal DAO activity was negatively correlated with plasma DAO activity, and changes in blood DAO activity reflected intestinal injury, and the changes were correlated with plasma endotoxin levels and bacterial translocation. The stress response produced by ...
Mitochondria have multiple functions, not only providing energy to cells through oxidative phosphorylation to produce ATP, but also involved in regulating processes such as calcium homeostasis, reactive oxygen species (ROS) production, cellular stress response and cell death. Mitochondria play a key role in maintaining cellular health and viability, and their ...
Messenger RNA pseudouridylation was recently discovered as a widespread and conserved phenomenon, but the mechanisms responsible for selective and regulated pseudouridylation of specific sequences within mRNAs still remain unknown. ...
"Abstinence from alcohol activates the stress system in the brain, which leads to recurrence, and in this study, we linked this stress response to CSF1 (a neuroimmune mediator), providing new opportunities for therapeutic intervention," said senior author Marissa Roberto, PhD, professor in the Department of Molecular Medicine at the Scripps ...