Tumor Infiltrating Articles & Analysis
6 articles found
The neoplastic cells often appear arranged in irregular, infiltrative patterns. Well-differentiated tumors may show tubule formation and minimal pleomorphism, whereas poorly differentiated varieties can present with significant nuclear atypia and a higher mitotic index. ...
One of the most significant applications lies in cancer immunotherapy. Tumors often manipulate chemokine pathways to evade immune surveillance. By administering recombinant chemokines, scientists can redirect immune cells to the tumor microenvironment, potentially enhancing the efficacy of checkpoint inhibitors or CAR-T cell therapies. For instance, CXCL10 has ...
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Besides the IL-2RG receptor subunit, the γc family cytokine receptors include IL-2RB ...
Chimeric antigen receptor T cells (CAR-T) and T cell antigen receptor chimeric T cells (TCR-T) are currently the "top stream" in adoptive T cell tumor immunotherapy. In particular, CAR-T therapy, which has been approved by the FDA, is rewriting the treatment paradigm of some hematological tumors. ...
Background Tumor immunotherapies compose immune checkpoint inhibitors, therapeutic antibodies, tumor vaccines, cellular therapies, and so on. ...
TCR-T immunotherapy boosts the host immune system by interacting effectively with MHC molecules, particularly class II molecules, which are uniquely recognized by TCR-T cells and CAR-T cells. CAR-T cells primarily detect tumor surface antigens, whereas TCR-T cells recognize intracellular tumor-specific antigens. ...