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Tumor Mutation Articles & Analysis
18 articles found
Circulating Tumor Cells, or CTCs, are cancer cells that have shed from the primary tumor and enter the bloodstream, where they can travel and potentially lead to metastasis. ...
This phenomenon offers a remarkable opportunity in cancer therapy. Tumors often exhibit mutations that can be exploited for targeted treatments. For example, patients with mutations in the BRCA1 or BRCA2 genes, which are crucial for DNA repair, are susceptible to drugs that inhibit PARP (Poly ADP Ribose Polymerase). ...
Discover how matched tumor-normal sequencing can help clinical researchers detect the somatic origin of variants with certainty. In the era of precision oncology, it has become increasingly common for patients diagnosed with cancer to undergo tumor sequencing. Identifying the mutations that make up a tumor’s genomic ...
This concept is vital in cancer studies as it helps track the development of tumor cells from a single mutated cell. Clonality analysis is thus essential in understanding the evolution and the spread of cancerous cells in a patient's body. ...
Brain tumors can be broadly categorized into primary and secondary (or metastatic) tumors. Primary tumors originate in the brain1, while secondary tumors spread from other body parts. ...
ESMO updated its recommendations for NGS in advanced cancers this year, urging broader use of NGS in additional cancer types and the inclusion of tumor-agnostic biomarkers. The ESMO Precision Medicine Working Group (PMWG) first published its recommendations for when to use next-generation sequencing (NGS) in routine practice for patients with metastatic cancers in 20201. At that time, based ...
This concept is vital in cancer studies as it helps track the development of tumor cells from a single mutated cell. Clonality analysis is thus essential in understanding the evolution and the spread of cancerous cells in a patient's body. ...
Enhancing Cancer Genomic Research with WES Mutations occurring within the whole exome regions of the cancer genome play a pivotal role in tumor development. ...
Researcher Insco said that we found that CDK13 protein can play the role of tumor suppressor in melanoma, and its mutation or deletion can lead to tumor occurrence. ...
Targets can be divided into tumor-specific antigens (TSA) and tumor-associated antigens (TAA) according to their expression. Antigens that are only expressed in tumor cells but not in normal cells are tumor-specific antigens and the most ideal targets; antigens that are lowly expressed in normal tissues but highly expressed in ...
P53 is a major component of the body's natural cancer defense system, which prevents cells from overgrowing and turning into tumors. Almost all cancers depend on mutations and failures of p53. But strangely, in most glioblastoma cases, p53 remained unharmed. ...
Traditional high-throughput sequencing methods are difficult to apply to transcriptome analysis of rare circulating tumor cells, the research of the earliest differentiation characteristics of human embryogenesis, and the study of tumor non-homogeneity and microevolution. For example, it is often impossible to determine whether two genetic ...
However, whether amino acid residues formed by genetic mutations directly induce or link nascent protein interactions (neoPPIs), which in turn lead to new functions of protein networks unique to tumor cells, has not been fully elucidated. ...
By conducting and integrating genomes databases, we have the ability to systematically analyze disease genomics, such as cancer genomics, to break through the limitations of analyzing high-throughput datasets, and to facilitate the understanding of complex issues such as molecular mechanisms of tumor formation, recurrence and drug resistance, tumor heterogeneity, ...
The development of drug resistance is associated with multiple factors, including the level of PD-L1 expression in tumor cells, the tumor microenvironment, and the mutational load of genes that determine the cancer-immunecheck point. Recent macrogenome sequencing studies reveal that the gut microbiota is another key mediator of this ...
Normal cells have quality-control mechanisms to ensure that mRNA is correctly transcribed from gene-coding regions in DNA, but tumor cells make frequent transcription mistakes, including adding or cutting out nucleotides to produce mRNA riddled with errors called frameshift mutations. ...
ByCalviri
Due to the large amount of data, these researchers were also able to compare the patient’s LAG+ immunophenotype with other known response biomarkers—specifically, PD-L1 status and tumor mutation burden. They found that this immunophenotype provides new and independent information about the patient's prognosis, rather than just echoing other ...
Cancer cells arise through sequential acquisition of mutations in tumor suppressors and oncogenes. c-Jun, a critical component of the AP-1 complex, is frequently overexpressed in diverse tumor types and has been implicated in promoting cellular proliferation, migration, and angiogenesis. ...