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Vaccine Trials Articles & Analysis

20 articles found

Peptide Vaccine Challenges: How to Enhance Stability and Efficacy?

Peptide Vaccine Challenges: How to Enhance Stability and Efficacy?

In recent years, many peptide vaccines targeting viruses (such as HIV, hepatitis B, SARS-CoV-2), bacteria (such as Mycobacterium tuberculosis), and tumor antigens (such as MAGE-A1, HER2) are in clinical trial stages, some advancing to late-stage research, showing broad application prospects. ...

ByBOC Sciences


A Milestone in Global Health: A New Polio Vaccine Approved for Emergency Use

A Milestone in Global Health: A New Polio Vaccine Approved for Emergency Use

In a significant stride towards eradicating a debilitating disease, a new polio vaccine has achieved WHO prequalification. This development represents a crucial milestone in global health, where effective vaccination remains our strongest defence. ...

ByB Medical Systems


FluGen Announces Completion of First Cohort in Age De-escalation Clinical Trial of M2SR Flu Vaccine Candidate in Pediatric Subjects Ages 6 Months to 17 Years

FluGen Announces Completion of First Cohort in Age De-escalation Clinical Trial of M2SR Flu Vaccine Candidate in Pediatric Subjects Ages 6 Months to 17 Years

MADISON, Wis., Sept. 7, 2022 /PRNewswire/ — FluGen, Inc., a clinical-stage vaccine company transforming vaccine efficacy in infectious respiratory diseases, today announced the completion of enrollment of the first cohort in an age de-escalation clinical trial of M2SR (M2 Deficient Single Replication) live virus vaccine, ...

ByFluGen, Inc.


Rational Vaccines Announces a Clinical Trial to Determine Baseline Characteristics of Patients Diagnosed With Recurrent Symptomatic Herpes Simplex Type 2 (HSV-2) Virus

Rational Vaccines Announces a Clinical Trial to Determine Baseline Characteristics of Patients Diagnosed With Recurrent Symptomatic Herpes Simplex Type 2 (HSV-2) Virus

Results will inform protocol design of Phase 1/2 clinical trial of Company's lead HSV-2 therapeutic vaccine candidate WOBURN, Mass. and OXFORD, England, Aug. 15, 2022 /PRNewswire/ -- Rational Vaccines, a company focused on revolutionizing the treatment and prevention of herpes to eradicate the disease, today announced the launch of a clinical ...

ByRational Vaccines, Inc.


RVx201 Herpes Vaccine

RVx201 Herpes Vaccine

NLS) have provided the following observations: Mice vaccinated with HSV-2 0?NLS showed an improved antibody response compared to vaccination with a subunit vaccine candidate, Mice immunized with HSV-2 ...

ByRational Vaccines, Inc.


Editorial: Research, Development and Clinical Trials for Peptide-Based Vaccines

Editorial: Research, Development and Clinical Trials for Peptide-Based Vaccines

Although vaccines against COVID-19 are unlikely to eradicate the disease in the way that the smallpox vaccine did, they have proved very effective in preventing death and hospitalisation, with enormous societal and economic benefits. There is now considerable research effort invested in building on the success of prophylactic vaccines in ...

ByOxford Vacmedix UK Limited


Nipah virus glycoprotein structure suggests therapeutic strategies

Nipah virus glycoprotein structure suggests therapeutic strategies

People infected with either of these diseases have a 50% to 100% chance of dying. There is already a vaccine approved for use on horses and a modified vaccine has entered human clinical trials. ...

ByCreative Biostructure


Preventive cancer vaccine based on neoantigens gets put to the test

Preventive cancer vaccine based on neoantigens gets put to the test

The study, called the Vaccination Against Canine Cancer Study, or VACCS, is the largest, most expensive interventional veterinary cancer trial to date. ...

ByCalviri


FluGen Initiates NIH-Funded Trial of M2SR Flu Vaccine; First Study in Adults Up to Age 85

FluGen Initiates NIH-Funded Trial of M2SR Flu Vaccine; First Study in Adults Up to Age 85

Carlos Fierro, Chief Medical Officer at Johnson County Clinical Trials, and Principal Investigator of the FluGen H3N2 v0005 clinical trial. ...

ByFluGen, Inc.


Medical Advancements

Medical Advancements

In the past few days, Moderna and Pfizer have released some promising clinical trials of their Covid-19 vaccinations. While these are still in the trial phase, many remain hopeful that the end of this deadly pandemic is near. ...

ByC&A Scientific


Will Covid-19 Vaccine Create a Dry Ice Shortage?

Will Covid-19 Vaccine Create a Dry Ice Shortage?

On November 9, 2020, Pfizer and BioNTech announced that their trial of a Covid-19 vaccine showed a 90% efficacy rate and very promising results in participants who had developed symptoms. ...

ByCoulson Ice Blast


Micron developing microneedle technology for self-administration of vaccines and therapeutics

Micron developing microneedle technology for self-administration of vaccines and therapeutics

“The concept of self-medication isn’t going away, even after the pandemic ends: we’ve learned to adapt to telemedicine, and the self-administration of therapeutics and vaccines isn’t far behind,” Mr. Damon contends. Micron has completed a Phase 1 clinical trial of a seasonal influenza vaccine based on its ...

ByMicron Biomedical, Inc.


The race to a vaccine - unintended consequences?

The race to a vaccine - unintended consequences?

A gold rush is on to find a vaccine for COVID-19. According to the World Health Association (WHO) in early May, there are more than 100 projects around the world centered on the development of a vaccine for the coronavirus. Eight candidate vaccines are already being tested in people in clinical trials. Once an effective ...

ByVistex Inc


UW–Madison, FluGen, Bharat Biotech to develop CoroFlu, a coronavirus vaccine

UW–Madison, FluGen, Bharat Biotech to develop CoroFlu, a coronavirus vaccine

CoroFlu could be in human clinical trials by the fall of 2020. Four Phase I and Phase II clinical trials involving hundreds of subjects have shown the M2SR flu vaccine to be safe and well tolerated. ...

ByFluGen, Inc.


Industry innovations for an equitable global distribution of COVID-19 vaccine

Industry innovations for an equitable global distribution of COVID-19 vaccine

With researchers ramping up efforts to develop a COVID-19 vaccine, progress has been achieved at unprecedented speed. In just two months, the first vaccine candidate entered clinical trials. ...

ByB Medical Systems


A Bayesian design for phase I cancer therapeutic vaccine trials

A Bayesian design for phase I cancer therapeutic vaccine trials

However, these designs are poorly applicable for the development of cancer therapeutic vaccines because the expected safety concerns for these vaccines are not as much as cytotoxic agents. The primary objectives of a cancer therapeutic vaccine phase I trial thus often include determining whether the vaccine shows ...

ByOxford Vacmedix UK Limited


The Major Breakthrough That Completely Stopped This Woman`s Painful Genital Herpes Outbreaks

The Major Breakthrough That Completely Stopped This Woman`s Painful Genital Herpes Outbreaks

The clinical trial Mel participated in was the first live-attenuated herpes vaccine tested on humans. ...

ByRational Vaccines, Inc.


Preliminary evidence of efficacy from an open label trial of a therapeutic AIDS vaccine derived from the blood of HIV-positive donors

Preliminary evidence of efficacy from an open label trial of a therapeutic AIDS vaccine derived from the blood of HIV-positive donors

Two earlier reported studies indicated the beneficial clinical effects of THIVAC, a therapeutic HIV vaccine derived from the blood of HIV-positive donors. However, in those studies no stringent statistical analysis to support the beneficial clinical outcome was attempted. ...

ByInderscience Publishers


HIV-1 subtype C vaccine: waiting in wings for the human trials

HIV-1 subtype C vaccine: waiting in wings for the human trials

India has more than 5 million people infected with HIV-1 and this number is likely to increase in coming years. It is estimated that by the turn of this decade more than 10 million people would have been infected with this virus. More than 90% of these infections are due to subtype C. Therefore, it is imperative that a vaccine be developed based on local circulating subtype and tested for ...

ByInderscience Publishers


Safety and immunogenicity of bivalent inactivated vaccine against haemorrhagic fever with renal syndrome in a phase II trial on healthy Chinese volunteers

Safety and immunogenicity of bivalent inactivated vaccine against haemorrhagic fever with renal syndrome in a phase II trial on healthy Chinese volunteers

This purified vaccine was tested in the clinical phase I/II trial in healthy non-infected adults in China. About 518 volunteers in Southern region and 650 volunteers from the Northern region of China were vaccinated. Volunteers then received one or two boosts at two weeks post-vaccination. ...

ByInderscience Publishers

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