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Vascularized Tissue Articles & Analysis
9 articles found
What is biofilm? Biofilms are defined as communities of micro-organisms attached to a surface, or one another, and encased within a matrix of extracellular polymeric substance (EPS). The EPS makes up the largest component of the biofilm, and in the biological environment is generally composed of polysaccharides, proteins, glycolipids, blood products, cellular debris, extracellular enzymes, metal ...
Structure of Matrix Metalloproteinase (MMP) Family In vertebrates, the MMP family consists of 28 members, at least 23 of which are expressed in human tissues, 14 of which are expressed in the vascular system. MMPs are usually classified into collagenases, gelatinases, stromelysins, matrilysins, membrane-type (MT)-MMPs, and other MMPs based on their substrates and the organization of their ...
Abstract : Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used to monitor flow rates and vascular diameters throughout the study. Intimal hyperplasia in the outflow vein of TEVGs was assessed at ...
Abstract The goal of this study is to develop unique native endothelium mimicking nanomatrices and evaluate their effects on adhesion and spreading of human umbilical vein endothelial cells (HUVECs) and aortic smooth muscle cells (AoSMCs). These nanomatrices were developed by self-assembly of peptide amphiphiles (PAs) through a solvent evaporation technique. Three PAs, one containing the ...
When trauma to the skin occurs, large areas of both the skin’s surface (epidermis) and deeper layers (dermis) may be destroyed. In many cases, large full-thickness wounds may require temporization due to the lack of suitable donor sites for primary skin grafting. Clinical research[1] indicates the temporization of deep, large wounds with dermal scaffolds can not only help provide ...
Objective: Patients with end stage renal failure who require haemodialysis suffer morbidity and mortality due to vascular access. Bioengineered human acellular vessels (HAVs) may provide a haemodialysis access option with fewer complications than other grafts. In a prospective phase II trial from 2012 to 2014 (NCT01744418), HAVs were implanted into 40 haemodialysis patients at three sites in ...
Highlights • AROA’s Myriad Matrix™ is further validated in a clinical study and peer-reviewed publication in Journal of Wound Care. • Study of six patients shows 100% success rates from use of Myriad Matrix™ as an implant during surgical reconstruction of soft tissues affected by Pilonidal Sinus Disease (PSD). • All patients healed well with no major complications ...
As a physical therapist for over 40 years, I have developed a core set of values, chief among them is dedication to lifelong learning. And the more I learn the more I realize how much I don’t know it’s a humbling, frustrating, energizing, exciting and exhausting realization. But at the same time, the more I learn the more I realize how connected and integrated so many of the ...
Publication Summary: Conventional cell therapy and tissue engineering approaches to treating liver diseases and injury are limited by low cell retention, poor engraftment, poor graft durability and complications including portal hypertension. Integration of next generation technologies such as 3D bioprinting is an essential step towards the clinical success of these promising approaches and has ...