Vegfr Articles & Analysis
5 articles found
"This is the first trial to show a survival benefit of ICI and VEGFR inhibition in patients with advanced lung cancer who have experienced tumor progression in a previous ICI," Reckamp said. Pembrolizumab is a class of immunotherapy drugs called immune checkpoint inhibitors (ICIs), while ramucirumab is a vascular endothelial growth factor receptor 2 (VEGFR-2) ...
Background Tumor immunotherapies compose immune checkpoint inhibitors, therapeutic antibodies, tumor vaccines, cellular therapies, and so on. However, each has its own set of issues, such as the fact that CAR-T therapy is an individual therapy that is costly; immune checkpoint inhibitors are highly effective, but only in some patients. The researchers expose us to a radically different way of ...
Several more representative FDA-approved marketed drugs contain hinge-bound heterocyclic backbones, many of which have been used to design highly active inhibitors of multiple target kinases, including VEGFR, Kit, B-Raf, EGFR, KDR, etc. The majority of lead compounds for small molecule kinase inhibitors can be obtained by high-throughput screening, virtual screening or ...
Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) is necessary for development of the blood vasculature during early embryogenesis, but later, VEGFR-3 expression becomes restricted to the lymphatic vasculature. We analyzed mice deficient in both of the known VEGFR-3 ligands, VEGF-C and VEGF-D. Unlike the Vegfr3–/– embryos, the ...
Ebola Virus (EBOV) presents a challenge for vaccine development because immune correlates of protection in humans are not well known. In earlier studies we developed a concept of local similarity which refers to resemblance of structural patterns of unrelated proteins as a function of their amino acid composition. The search for local similarities between human and EBOV proteins was performed. ...