Endocrine Disruptive Articles & Analysis
32 articles found
The study of cardiovascular biology is essential for understanding the mechanisms that regulate heart function and vascular health. As cardiovascular diseases remain the leading cause of death worldwide, advancements in this field offer crucial insights for developing new treatments and preventive strategies. Understanding the Cardiovascular System The cardiovascular system comprises the heart, ...
Removal of API’s, EC’s & EDC’s via Nyex Rosalox™ Technology We recently discussed the removal of active pharmaceutical ingredients (API’s) and emerging contaminants (EC’s) in the environment – see Removal of Active Pharmaceutical Ingredients from Water . Endocrine Disrupting Chemicals (EDCs) is another category of compounds whose presence in the ...
ByCoftec
It has been well proven that endocrine-disrupting chemicals (EDCs) can accumulate in river sediments. However, less is known about the possible remobilisation of sediment-bound EDC as a result of floods, bioturbation or dredging. A recent study, published in Elsevier’s Water Research journal focused on oestrogenic compounds accumulated in sediments along the German River Luppe – a ...
In this article we examine the legal and political moves to regulate endocrine disruptors over the past 20 years and the most recent developments in this regard… There is growing concern in the EU and worldwide about the negative human health and environmental impacts possibly caused by endocrine disruptors. So, what are endocrine disruptors (ED)? They are chemicals that may interfere ...
Endocrine disrupting compounds (EDCs) can impact the reproductive system by interfering with the hypothalamic‐pituitary‐gonadal (HPG) axis. While in vitro testing methods have been developed to screen chemicals for endocrine disruption, extrapolation of in vitro response to in vivo action shows inconsistent accuracy. We describe here our tissue co‐culture of the fathead minnow (Pimephales ...
Phthalic acid esters are frequently detected in aquatic environment. In this study, zebrafish were exposed to low concentrations (0, 0.46, 4.0, and 37.5 µg/L) of mono‐(2‐ethylhexyl) phthalate (MEHP) for 81 days, and the effects on reproduction, gamete quality, plasma vitellogenin (VTG), sex steroids, and transcriptional profiles of key genes involved in steroidogenesis were investigated. The ...
The goal of the present study was to evaluate the reproductive function of fathead minnows (Pimephales promelas) exposed to brominated diphenyl ether 47 (BDE‐47) at doses lower than used in previous studies. This was accomplished by evaluating the impacts of BDE‐47 exposures across multiple levels of biological organization. Breeding pairs were exposed to BDE‐47 via diet for 21 days during ...
Direct linkages between endocrine‐disrupting compounds (EDCs) from municipal and industrial wastewaters and impacts on wild fish assemblages are rare. The levels of plasma vitellogenin (Vtg) and Vtg mRNA in male fathead minnows Pimephales promelas (FHMs) exposed to wastewater effluents and dilutions of 17α‐ethinylestradiol (EE2), estrogen activity, and fish assemblages in 10 receiving streams ...
Previous studies have demonstrated that some amphibian species can be sex‐reversed by high concentrations of androgens. Little attention has focused on the effects of androgenic endocrine‐disrupting chemicals (EDCs) on amphibians. The present study aimed to investigate the effects of lower concentrations of the androgenic EDC 5α‐dihydrotestosterone (DHT) on gonadal differentiation and ...
The GWAVA model, incorporating regional water abstractions and reservoir information, was used to model human‐sourced steroid estrogens: estrone (E1) and estradiol (E2) in the Yellow River catchment. The river flows in the main stem were calibrated using gauged flows. Following a review of Chinese data on estrogen discharge from a range of sewage treatment plants, low, median and high ...
The chemical UV filter benzophenone‐3 (BP‐3) is suspected to be an endocrine disruptor based on results from in vitro and in vivo testing. However, studies including endpoints of endocrine adversity are lacking. The present study investigated the potential endocrine disrupting effects of BP‐3 in zebrafish (Danio rerio) in the Fish Sexual Development Test (OECD TG 234) and a 12 day adult male ...
Pharmaceuticals and personal care products (PPCPs) are emerging contaminants that have been found ubiquitously in wastewater and surface waters around the world. A major source of these compounds is incomplete metabolism in humans and subsequent excretion in human waste, resulting in discharge into surface waters by wastewater treatment plant (WWTP) effluent. One pharmaceutical found in ...
As knowledge of contaminants capable of adversely modulating endocrine functions increases, attention is focused on the effects of synthetic progestins as environmental endocrine disrupters. In the present study, effects of exposure to a synthetic progestin (norethindrone, 168 ± 7.5 ng/L) and endogenous progestogen (progesterone, 34 ± 4.1 ng/L) on steroidogenesis in adult female fathead minnows ...
Exogenous growth promoters have been used in United States beef cattle production for over 50 years. The environmental fate and transport of steroid growth promoters suggest potential for endocrine disrupting effects among ecological receptors; however, the initial excretion of steroid metabolites from cattle administered growth promoters has not been well characterized. To better characterize ...
The aim of the present study was to investigate the effects of the androgenic endocrine disruptor 17β‐trenbolone on the sexual development of zebrafish (Danio rerio) with special emphasis on the question whether adverse outcomes of developmental exposure are reversible or persistent. An exposure scenario including a recovery phase was chosen to assess the potential reversibility of androgenic ...
Inter‐specific differences in xenobiotic metabolism are a key to determining relative sensitivity of animals to xenobiotics. However, information in domesticated livestock, companion animals, and captive and free‐ranging wildlife is incomplete. The present study evaluated inter‐specific differences in phase‐II conjugation using pyrene (PY) as a non‐destructive biomarker of polycyclic aromatic ...
Exposure to certain environmental contaminants such as agricultural pesticides can alter normal endocrine and reproductive parameters in wild fish populations. Recent studies have found widespread pesticide contamination across the rivers that discharge into the Great Barrier Reef lagoon. Potential impacts on native fish species exposed to known endocrine disrupting chemicals such as atrazine, ...
Our objective was to investigate the impact of Polybrominated diphenyl ethers (PBDEs) on fish reproduction over two generations. Zebrafish (Danio rerio) embryos (F0) were exposed to low concentrations (3, 10, 30 μg/L) of the PBDE mixture DE‐71 until they were sexually mature, and steroid hormone production, expression of genes involved in steroidogenesis, gonadal development and gamete ...
Mercury can disrupt the endocrine systems of mammals and fish, but little is known about its effects on avian hormones. We employed an experimental manipulation to show that methylmercury suppresses the stress‐induced corticosterone response in birds, an effect previously unreported in the literature. Corticosterone regulates many normal metabolic processes, such as the maintenance of proper ...
Pharmaceutical and personal care products (PPCPs), some of which have endocrine disrupting effects at environmentally relevant concentrations, have been detected in many surface waters. We evaluated the effects of two common endocrine disrupting PPCPs on the life history traits of the snail, Physa pomilia, using a life table response experiment with snails raised in environmentally relevant ...