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Intestinal Absorption Articles & Analysis
5 articles found
In the realm of pharmacology and drug development, the assessment of drug permeability is essential. One of the most widely recognized in vitro models for evaluating the intestinal absorption of compounds is the Caco-2 permeability assay. This assay plays a pivotal role in understanding how drugs are absorbed in the gastrointestinal tract and aids in predicting their bioavailability. Background ...
The MDCK permeability assay is a critical technique employed in pharmacology and drug development to evaluate the permeability of drug candidates across epithelial cell layers. This assay utilizes Madin-Darby Canine Kidney (MDCK) cells, which are a widely used model for studying intestinal absorption and permeability due to their similarity to human epithelial cells. Importance of the MDCK ...
Intestinal inflammatory diseases are highly complex, which has thus far prevented development of an effective in vitro disease model. With access to a donor-derived cell biobank and the ability to recapitulate region-specific environments of the intestine, Altis Biosystems is working toward the development of an in vitro RepliGut® model to accurately recapitulate the complex intestinal ...
Oral administration of bio–macromolecules is an uphill task and the challenges from varying pH and enzymatic activity are difficult to overcome. In this regard, nanotechnology promises the new hope and offers advantages such as controlled release, target specific delivery, combinatorial therapy and many more. In this study, we demonstrate the formulation of a novel alginate enclosed, chitosan ...
The activity of detoxifying enzymes and glucose absorption were measured in the digestive tract of Helix aspersa exposed to nickel. Nickel decreased CAT activity and, in the lower concentration, inhibited intestinal absorption of glucose. Elevated AChE activity and unchanged GST activity indicate diversity in enzymatic response to nickel. Nickel at higher concentration, destroying the intestinal ...