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Bioinformatics Analysis Articles & Analysis
35 articles found
This article outlines best practices for the bioinformatics analysis of 16S rRNA sequencing, emphasizing the critical stages of data preprocessing and quantification. Bioinformatics Pipeline Overview The bioinformatics pipeline for 16S rRNA sequencing can be broadly divided into two main stages: data preprocessing and ...
The detailed point is to sequence the unknown genome sequence, and use bioinformatics analysis means to splice and assemble the sequence, so as to obtain the map of its genome. For coverage, the genome sequence assembled after sequencing analysis usually cannot completely cover all regions due to the existence of gaps in large segments of ...
Navigating the Path from Wet Lab to Dry Lab The high-throughput sequencing of pathogens necessitates a two-fold process: wet lab experimentation and subsequent bioinformatics analysis. Wet lab endeavors encompass sample pretreatment, nucleic acid extraction, library construction, and ultimately, sequencing. Meanwhile, dry lab bioinformatics ...
Meanwhile, it's a useful tool for studying disease occurrence and progression, pharmacological action, bio-developmental molecular mechanisms, and more. Workflow and Bioinformatic Analysis Pipelines of RNC-mRNA Sequencing There are four major steps in the RNC-mRNA sequencing workflow: (1) sample preparation, (2) library preparation, (3) sequencing, and (4) data ...
These providers leverage state-of-the-art molecular biology techniques and bioinformatics tools to deliver clonality analysis services tailored to client needs. ...
It can be used to confirm the amino acid sequence of recombinant collagen, providing detailed molecular information on the protein, including molecular weight and potential modifications.With the progression of technology, more advanced analytical techniques, such as protein chips, high-throughput sequencing, and bioinformatics analysis, are gradually being ...
This technology identifies the diversity and specificity of T cells by measuring the sequences of the rearrangement regions of the TCRβ chain or α chain genes.(1) Sample Preparation: Total RNA or DNA is extracted from blood, tissue, or other samples enriched with immune cells.(2) Amplification: PCR amplification is performed using specific primers for multiple regions of the TCR genes, increasing ...
The result of the sequencing is a set of base combinations of the antibody sequence.Data AnalysisThe sequencing results are input into a computer, and data analysis is performed through bioinformatics software to identify the antibody sequence with immune activity.Experimental VerificationThe identified antibody sequence is validated in the laboratory, such as by ...
The company is based on Thermo Fisher's Q ExactiveHF mass spectrometer, Orbitrap Fusion mass spectrometer, Orbitrap Fusion Lumos mass spectrometer combined with Nano-LC and rich biological analysis experience, and has established a new generation of protein, peptide, and antibody sequencing platforms. You only need to tell us the purpose of the experiment and send the samples, ...
The design of antibody drugs is a complex and delicate process, and its success often depends on a deep understanding and precise analysis of the antibody itself. In this process, antibody sequencing plays a crucial role. ...
Structural Variant Analysis: SVs, or variations in the structure of an organism's chromosome, are studied. ...
As the technology matures, so does the bioinformatics analysis of ONT data. Researchers have been diligently developing specialized tools and algorithms to better utilize the unique characteristics of ONT data, such as long read lengths and ionic current signals. ...
These providers leverage state-of-the-art molecular biology techniques and bioinformatics tools to deliver clonality analysis services tailored to client needs. ...
Methods for detecting RNA modifications Currently, most methods used to detect RNA modifications fall into three categories: high-throughput whole-transcriptome sequencing technologies, mass spectrometry methods, and bioinformatics analysis. While the advent of next-generation sequencing provides a wealth of sequence information in a single run, it requires ...
Small RNA sequencing, an example of targeted sequencing, is a powerful method for small RNA species profiling and functional genomic analysis. Here, we present the guidelines for bioinformatics analysis of small RNA sequencing. ...
CD Genomics is a world-leading genomics services company that continues to innovate in high throughput sequencing services for the genomics industry, as well as genotyping, bioinformatics, microarrays, and more. The company has recently launched TCR-seq, a powerful service that enables rapid and efficient analysis of T-cell receptor (TCR) diversity and clonality, ...
And what are the most appropriate computational methods and analysis tools for this purpose? In this review, we focus on the bioinformatics pipeline of whole exome sequencing (WES). ...
Unlike amplicon sequencing, metagenomics obtains and investigates genetic material directly from environmental samples, which has led to a new understanding of the diversity and function of the microbial world. Bioinformatics analysis is one of the most important procedures for this purpose. Bioinformatics pipeline for viral metagenomics The ...
Sequencing the entire microbial genome is important for construction of accurate reference genomes, microbial identification, and other comparative genomic studies. Comparative genomic analysis based on whole genome sequencing plays an irreplaceable role in studying pathogenic mechanisms of pathogenic microorganism, evolution of pathogenic genes and screening of novel, efficient ...
· Reproductive tract The microorganisms in reproductive tract are important for women's health, reproductive function and infant's birth. 16S/18S/ITS amplicon sequencing can obtain the information of most microorganisms in the genital tract. Through bioinformatics/statistical analysis, a large number of data are processed and analyzed to find the ...