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Chemotherapy Articles & Analysis
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Application Examples: Using ApoE as a backbone allows LNDs to be specifically targeted to liver cells; LNDs with an ApoA1 backbone can be used for tumor treatment and can even carry chemotherapy drugs and immune adjuvants for a combined attack. Highlights: Their strong natural targeting properties make them particularly suitable for applications in anti-tumor and anti-fungal ...
Adjuvant therapies may include radiation, chemotherapy, and targeted therapy. The choice of therapy typically hinges on the tumor’s receptor status and specific genetic mutations. ...
This targeted approach enhances the therapeutic index of the drug, resulting in improved efficacy and reduced side effects compared to conventional chemotherapy. Development Process Developing an ADC involves several critical stages, including target selection, antibody engineering, linker optimization, and drug loading. ...
The classification of anti-tumor APIs often falls into four main types: chemotherapy drugs, targeted therapy drugs, immunotherapy drugs, and hormone therapy drugs. Each of these targets the malignancy through different mechanisms, offering multiple ways to tackle the disease. Chemotherapy APIs function by disrupting cell division processes, which inhibits the ...
This tailored approach not only enhances efficacy but also minimizes the adverse effects commonly associated with traditional chemotherapies. Exploring Parthanatos Parthanatos, a term derived from "Partha," the Sanskrit word for death, describes a unique form of programmed cell death that is distinct from apoptosis (the typical form of programmed cell death) and necrosis (a ...
Combination Therapies: Immuno-oncology can be combined with other treatment modalities, including surgery, radiation, and chemotherapy, to optimize patient outcomes. Challenges and Considerations While immuno-oncology presents promising advancements, it also comes with challenges. ...
Traditional treatments, including chemotherapy and radiation, while effective for some, often come with severe side effects and varied success rates. ...
ADCs combine the specificity of monoclonal antibodies with the destructive capabilities of cytotoxic drugs, enabling targeted delivery of chemotherapy directly to cancer cells while sparing healthy tissues. The customization aspect of ADCs development allows for the tailoring of both the antibody component and the cytotoxic agent, maximizing efficacy against specific breast ...
Possible causes of fructose malabsorption are: · Inherited or acquired abnormality of the fructose-transporting protein · Overuse of high fructose corn syrup or fruit juices in children · SIBO · Celiac disease · Chemotherapy or radiation · Dumping syndrome Symptoms of fructose intolerance can ...
Treatment options traditionally include surgery, radiation therapy, and chemotherapy. However, these approaches can be invasive and have severe side effects. ...
Compared to other solid tumors, pancreatic cancer (PC) lacks effective therapy with poor outcomes. PC is highly resistant to chemotherapy and radiotherapy due to its systemic aggressive nature, complex mutational environment, and desmoplastic stroma. ...
At present, some commonly used technologies for breast cancer treatment include surgery, chemotherapy, radiation therapy, hormone therapy, targeted therapy, and immunotherapy. ...
Although frontline treatment of chemotherapy and surgery is often effective, with nearly all patients experiencing remission, over 80% of patients will experience disease recurrence in the first two years and ultimately die of the disease. ...
On the other hand, combining monoclonal antibodies with traditional chemotherapy has shown promising results in the treatment of certain types of cancer. ...
SN38 is the active metabolite of the prodrug irinotecan, commonly used in chemotherapy. It's known for its high potency against cancer cells but has limitations in terms of bioavailability and solubility. ...
In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the therapeutic index while providing selective delivery. ...
Introduction Chemotherapy with anti-tumor agents is currently one of the most important systemic treatments for cancer. ...
Examples of drug-loaded liposomes Several liposomal drug formulations have already been approved for clinical use, including: Doxil: This liposomal form of doxorubicin, a chemotherapy drug, is used to treat cancer. It has shown improved tumor targeting and reduced side effects compared to the free drug. ...
Actinomycin D has been used in cancer chemotherapy. Most other AMPs are too toxic for systemic administration but can be safely used topically on the skin for superficial cuts and abrasions. ...
Targeting of triple negative breast cancer cells by disulfiram Triple negative breast cancer (TNBC) refers to breast cancer that is negative for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her-2), which can only be treated clinically with radiotherapy and chemotherapy. Robinson et al. used a high-throughput screening method to ...