- Home
- Articles
- north america
- dna protein
Refine by
Dna Protein Articles & Analysis
48 articles found
The Strategic Role of Downstream Processing The primary objective of downstream development is to separate the product of interest from a complex mixture containing host cell proteins, DNA, endotoxins, aggregates, and media components. Unlike small molecules, biologics are delicate and structurally complex, requiring gentle yet selective purification. ...
Understanding sgRNAs sgRNAs are short RNA sequences that guide the Cas9 protein to the target DNA. Typically, they consist of approximately twenty nucleotides complementary to the target DNA sequence, paired with a scaffold region that recognizes and binds to Cas9. ...
Lysine Acetylation: This is a reversible modification that occurs on the ε-amino group of lysine residues within a protein. By neutralizing the positive charge of the lysine side chain, it can dramatically alter a protein's structure and its interactions with other molecules, such as DNA, RNA, and other proteins. ...
Through its impact on translation efficiency and mitochondrial function tRNA methylation modification also promotes tumor cell proliferation by controlling cell cycle-related protein expression. Cell cycle progression within cells is a critical biological function whose stoppage and progression rely entirely on cell cycle-related protein expressions. ...
Egg white is the richest source of lysozyme, containing approximately 3.5% of its total protein content. This abundance makes egg white extraction the most common method for industrial lysozyme production. For large-scale applications, recombinant DNA technology has been employed to produce highly pure lysozyme for research and commercial purposes. ...
Microarray printing is a high-throughput technique used to create arrays of biological molecules—such as DNA, RNA, proteins, or glycans—on a solid surface, usually a glass slide or membrane. ...
Let me tell you a story about how these remarkable protein catalysts are transforming the future of mRNA technology and, in turn, revolutionizing modern medicine. ...
Recombinant protein drugs are therapeutic protein drugs produced using DNA recombination technology or other biotechnologies. ...
It is mainly used in component separation: desalination, replacement of buffers, removal of harmful reagents, purification of biomolecules such as proteins, peptides, and polysaccharides, calculation of molecular size and molecular homogeneity, etc. ...
With technological advancements, we now have more novel avenues to choose from, such as recombinant proteins, engineered cells, and DNA encoding proteins, all of which can display a variety of epitopes or potential antibody recognition sites. Compared to these newer forms of antigens, peptides may be slightly lacking in epitope coverage, as they ...
Difficult to Target Antigens and Novel Drug TargetsDifficult-to-target antigens and novel drug targets are major challenges in antibody discovery and antibody drug design. Transmembrane protein receptors and other targets account for 20-30% of the human proteome and 60% of current drug targets. ...
This innovative process holds great promise in unlocking new possibilities in scientific research, paving the way for exciting advancements in the biotechnological landscape Messenger RNA plays a crucial role in the genetic code of all living organisms, transferring instructions from DNA to ribosomes for protein synthesis. Through custom mRNA production, ...
Protein-Protein Interaction databases primarily record experimentally validated protein interaction data. Here are some key Protein-Protein Interaction databases:BioGRID(Biological General Repository for Interaction Datasets)BioGRID is a database focused on biological molecular interactions, including ...
Upon autophagy initiation, microtubule-associated protein 1 light chain 3 (LC3) is converted from LC3-I to the lipidated LC3-II and anchored to the autophagic membrane. ...
What is CRISPRi? The dCas9 fusion protein targets DNA sequences through sgRNA, but the inactive dCas9 cannot catalyze DNA. Instead, a protein fused to dCas9 manipulates the transcription of the target gene. ...
The ubiquitination site of a protein refers to those specific amino acid residues on the protein molecule that can covalently bind with Ubiquitin. ...
It is mainly used in component separation: desalination, replacement of buffers, removal of harmful reagents, purification of biomolecules such as proteins, peptides, and polysaccharides, calculation of molecular size and molecular homogeneity, etc. ...
Compared with other carrier materials, PLGA nanocarriers have the following advantages: It is polymerized by glycolic acid and lactic acid, and the synthesis process is relatively mature; The nanoparticle size is controllable, uniform in size and small in dispersion; It can achieve long-term sustained release of carrier drugs (several weeks or months), reduce the frequency of medication, and ...
Protein fusion is a genetic recombination technique in which the DNA of an inactive peptide or protein chain segment to be grafted is recombined with the DNA of a drug and expressed together by engineered cells; no specialized grafting operations are required. ...
This information helps researchers optimize drug design and select the most promising candidates for further development. Protein-Protein Interactions Understanding protein-protein interactions is essential for deciphering cellular processes and developing targeted therapies. MST allows researchers to study these interactions ...