Chronic Inflammatory Articles & Analysis
13 articles found
ELANE, or neutrophil elastase (NE), is a serine protease stored in the azurophilic granules of neutrophils and is encoded by the ELANE gene on chromosome 19. It plays a pivotal role in the host defense system by degrading bacterial proteins, remodeling extracellular matrices, and shaping inflammatory responses. However, the same proteolytic activity that protects against pathogens can, when ...
Introduction PEGylation, the process of attaching polyethylene glycol (PEG) chains to therapeutic molecules, has become a cornerstone in pharmaceutical development. This technique improves the pharmacokinetic and pharmacodynamic properties of drugs, enhancing their stability, solubility, and circulation time while reducing immunogenicity. Since its first FDA-approved application in 1990 with ...
Chemokines are a specialized subset of small cytokines that play a crucial role in the immune system by directing the movement of circulating leukocytes to sites of inflammation, infection, and injury. Acting as chemoattractant molecules, chemokines are central to both innate and adaptive immunity, influencing not only immune surveillance but also wound healing and angiogenesis. Over the past few ...
The field of medical science has long utilized disease models, which are systems simulating the progression and expression of a disease, to better understand various illnesses. These models facilitate the study of disease pathology, identifying underlying mechanisms, and developing potential treatments. In the context of respiratory diseases, numerous models have been developed, with a prominent ...
The field of medical science has long utilized disease models, which are systems simulating the progression and expression of a disease, to better understand various illnesses. These models facilitate the study of disease pathology, identifying underlying mechanisms, and developing potential treatments. In the context of respiratory diseases, numerous models have been developed, with a prominent ...
The MMP Family Matrix metalloproteinases (MMPs) are a family of enzymes belonging to the metzincin superfamily. There are 23 different types of secreted or membrane-anchored endopeptidases in the human body. MMPs are capable of degrading ECM proteins such as collagen, gelatin, laminin, fibronectin, fibrinogen, elastin, and proteoglycans. They were once considered regulators of the extracellular ...
Purpose Dysregulations of key signaling pathways in metabolic syndrome are multifactorial, eventually leading to cardiovascular events. Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated lipid peroxidation with further development of atherosclerotic alterations and diabetes. We ...
Sugar is a direct source of sweetness that not only enhances the flavor of food but also serves as a source of energy for the body. Sugar is used in everyday life to give us a "sweet" feeling, whether it's in candy, cake, or cola. Sugar consumption is quickly increasing as material living standards rise, which not only leads to an increase in obesity rates, but also increases various health ...
Highlights • AROA’s Myriad Matrix™ is further validated in a clinical study and peer-reviewed publication in Journal of Wound Care. • Study of six patients shows 100% success rates from use of Myriad Matrix™ as an implant during surgical reconstruction of soft tissues affected by Pilonidal Sinus Disease (PSD). • All patients healed well with no major complications ...
Cryotherapy Cryotherapy (also known as cold therapy) is broadly defined as the use of very cold temperatures for medical or general wellness purposes. Modern cryotherapy (which comes from the Greek kyro, meaning “cold” and therapeia, meaning “healing”) can be traced back thousands of years, and some form of it was practiced by the ancient Greeks, Romans, and Egyptians, ...
HBOT is a very effective adjunctive treatment for Rheumatoid Arthritis procedures Rheumatoid arthritis is a chronic inflammatory autoimmune disorder that can affect the lining of the joints and cause painful swelling that will result in the erosion of bones and the deformation of joints, which aggravated, leads to physical disabilities. As an autoimmune disorder, rheumatoid arthritis ...
This case study is presented to highlight how medical calculators can be useful clinical decision making tools for celiac disease diagnosis. Throughout the discussion, links to medical calculators that healthcare providers can use are provided. Incorporating these resources into a clinician’s workflow can lead to better outcomes through more accurate diagnoses and better management for this ...
Ankylosing Spondylitis (AS) is a rheumatic disease and almost 50% of the affected patients suffer from osteoporosis. The ratio of Receptor Activator of Nuclear Factor κB Ligand (RANKL) and Osteoprotegerin (OPG) has become an important marker to assess the status of systemic bone metabolism and has been shown to be dysregulated in AS patients. Combined Low-Dose Radon- and Hyperthermia Therapy ...