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Mitochondrial Activity Articles & Analysis
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Understanding Plant Cell Viability Plant cells, like all living cells, undergo a complex cycle of growth, differentiation, and death. In plant biotechnology, tissue culture, and stress physiology studies, knowing whether cells are alive or dead is essential for interpreting experimental results. Plant cell viability refers to the proportion of living, metabolically active cells in a given ...
In this study, researchers examine the effects of two drugs, everolimus and metformin, on triple-negative breast cancer. Everolimus blocks a protein called mTOR, while metformin blocks part of the mitochondria, the energy powerhouses of cells. They found that everolimus reduced products of the tricarboxylic acid (TCA) cycle, a key energy-producing process, and inhibited an enzyme called ...
Introduction Cellular mechanisms driving cell death play a crucial role in various physiological and pathological processes. One such mechanism is apoptosis, a tightly regulated process vital for maintaining tissue homeostasis, development, and immune response. Apoptosis assays are valuable tools used by researchers to study the intricate details of this cellular event. This blog aims to ...
Bees have a crucial role in pollination; therefore, it is important to determine the causes of their recent decline. Fipronil and imidacloprid are insecticides used worldwide to eliminate or control insect pests. Because they are broad‐spectrum insecticides, they can also affect honeybees. Many researchers have studied the lethal and sublethal effects of these and other insecticides on ...
Repair of oxidative DNA damage in mitochondria was thought limited to short-patch base excision repair (SP-BER) replacing a single nucleotide. However, certain oxidative lesions cannot be processed by SP-BER. Here we report that 2-deoxyribonolactone (dL), a major type of oxidized abasic site, inhibits replication by mitochondrial DNA (mtDNA) polymerase and interferes with SP-BER by covalently ...