Aldevron, LLC products

The gWiz plasmids are designed for the highest level of gene expression in a wide range of mammalian cells and tissues. They contain a proprietary modified promoter, followed by intron A from the CMV immediate early gene, and a high-efficiency artificial transcription terminator. gWiz expression vectors are constructed using a plasmid backbone that has been extensively modified to achieve enhanced levels of transgene expression in mammalian cells.

pCMV-S (also known as pRc/CMV-HBs) is widely used to validate DNA vaccine delivery and formulation strategies. This plasmid expresses the hepatitis B surface antigen (HBsAg) under the control of the CMV immediate-early promoter. pCMVHB-S2.S expresses the small and middle forms of recombinant HBsAg. The plasmid can be used to generate anti-HBsAg antibodies like pCMV-S. It is also used to fuse other sequences to the S form of HBsAg.