136 services found
Creative Biolabs services
Antibody Design and Conjugation
To retain antibody bioactivity, mild, near-physiological conditions are often used for conjugation reactions. Under these conditions, endogenous amino acids such as Lys and Cys are chemically reactive and can be used as conjugation sites.
ADC In Vitro Analysis
The construction of an antibody-drug conjugate (ADC) is the covalent coupling of a monoclonal antibody and a toxic payload drug via a linker molecule. The ultimate goal for an ADC development project is to deploy the resulted ADC into in vivo systems, both in model animals and eventually human patients, to cure cancer and other diseases utilizing its payload efficacy. However, prior to in vivo deployment, information regarding basic biochemical characteristics and in vitro efficacy must be acquired for a proper evaluation of the ADC to determine the proceedings and directions of the project.
Antibody Design and Conjugation
As one major component of an antibody-drug conjugate (ADC), the antibody is the key for target specificity and serves as the cargo to deliver the cytotoxic drug (payload). A payload drug can be attached to different sites on an antibody using diverse conjugation chemistry. Multiple endogenous amino acids can serve as potential conjugation sites. However, to achieve more precisely controlled site-directed conjugations and subsequently a narrower distribution of drug-to-antibody ratio (DAR), special moieties with unique conjugation chemistries are engineered into antibody sequences in our antibody design services.https://www.creative-biolabs.com/adc/antibody-design-and-conjugation.htm
ADC Pharmacokinetics Characterization
Pharmacokinetics (PK) studies provide critical information regarding the behavior of a drug in circulation and its ultimate form after extensive in vivo metabolism. Results from PK studies often serve as guidelines for clinical trials designs, especially in the development of an antibody-drug conjugate (ADC). Due to the heterogeneous nature of ADCs, multiple analytes have to be assessed to reveal the ADC PK characteristics, making these studies more complex.
https://www.creative-biolabs.com/adc/adc-pharmacokinetics-characterization.htm
ADC Linkers
Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC.
https://www.creative-biolabs.com/adc/classify-adc-linkers-7.htm
Antibody Design and Conjugation
One downside in using the endogenous amino acids for ADC development is a heavily dispersed drug-to-antibody ratio (DAR) caused by the non-uniform distribution of the conjugation sites, especially in the case of Lysine-based conjugations.
https://www.creative-biolabs.com/adc/antibody-design-and-conjugation.htm
One-Stop ADC Development Service
A successful ADC should be chemically and physiologically stable in blood stream, exert similar antigen binding pattern compared with the unconjugated antibody, and exhibit desired payload toxicological effects once internalized.
https://www.creative-biolabs.com/adc/one-stop-adc-development-service.htm
γδ T Cell Therapy Development Services for Tumors and Cancers
γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains. Compared to αβ T cells, γδ T cells without MHC restriction on tumor antigen recognition have strong cytotoxic effects on tumor cells. γδ T cells have been considered as wonderful effector cells for cancer immunotherapy. Creative Biolabs is an excellent expert in γδ T cell research and γδ T cell based immunotherapy. We provide a series of high-quality services for the development of γδ T cell based immunotherapy.https://gammadelta-t-therapy.creative-biolabs.com/t-cell-therapy-development-services-for-tumors-and-cancers.htm
γδ T Cell Therapy Development for Pathogen Infections
Activation and proliferation of γδ T cells play a significant role in diverse infectious diseases induced by bacteria, viruses, and parasites and exert their potential effector function to effectively eliminate the infection. Creative Biolabs is harnessing the unique properties of γδ T cells to develop potent and targeted pathogen infection disease therapies for research use. We also offer γδ T cell-related protein and antibody products for worldwide customers.
γδ T Cell Therapy Development Services for Autoimmune Diseases
Autoimmunity is a condition in which the immune system responds to and attacks self-antigens or self healthy cells and tissues. Autoimmunity to self-antigens or a low level of autoimmunity is considered to be beneficial and important to self-defense mechanisms and immune surveillance. However, an aberrant autoimmune response that the immune system attacks and damages healthy body tissues or organs by mistake can result in a series of autoimmune diseases. The pathogenesis of autoimmune diseases is extremely sophisticated, which is closely related to immune dysregulation involving a breach of autoantibodies and autoreactive T cells.
