Creative Biolabs services

Creative Biolabs has extensive experience to offer the novel human or humanized antibody services for either therapeutic or laboratory applications. We have three routes in developing human antibodies. The first and most straightforward method is to screen our human antibody libraries. The second method is to immunize premade “humanized” mice and then raise hybridoma cell lines [or to create an immune humanized antibody library] that produce human antibodies. The third method is antibody humanization. We rely on animals to produce non-human antibodies using either hybridoma or immune antibody library screening and screening methods; after that, the top candidate is humanized.

Antibody characterization is important in research and biopharmaceutical development. All therapeutic proteins produced from current technologies have heterogeneities in the final product because various modifications occur during different stages of production. Due to these heterogeneities, thorough characterization is necessary for the reproducible and safe production of therapeutic proteins.

Label-free interaction analysis is of great importance for scientists to study interactions between biomolecules. Scientists from Creative Biolabs are competent for performing antibody affinity and kinetics measurement with the most advanced Biacore, ProteOn, Octet systems, etc. These systems are mainly based on the optical phenomena technologies - surface plasmon resonance (SPR) and bio-layer interference (BLI), which enable a direct detection and measurement of molecular interactions in a real-time monitoring manner.

With years of experience in the field of antibody development, Creative Biolabs has established a high-accuracy sequencing platform to provide top quality antibody sequence determination services from hybridoma cell lines. Creative Biolabs’ hybridoma sequencing service is highly versatile and is applicable for both IgG and IgM types of monoclonal antibodies produced by mouse and rat hybridoma cell lines. We are dedicated to providing first-class customized service to contribute to the success of your project.